摘要
目的:探讨血浆可溶性致癌抑制因子2(sST2)、白细胞介素-33(IL-33)对儿童噬血细胞综合征(HPS)的诊断及预后预测价值。方法:选取2019年6月—2022年9月本院收治的30例HPS患儿为HPS组,记录其临床资料及实验室指标,并根据生存结局分为存活组20例和死亡组10例;选取非HPS的30例感染患儿为感染组;同期选取本院门诊体检的30例健康儿童为健康组。采用酶联免疫吸附(ELISA)法检测血浆sST2、IL-33水平;血浆sST2、IL-33水平对HPS的诊断及预后预测价值采用受试者工作特征曲线(ROC曲线)分析;采用logistic多因素回归分析HPS患儿预后的影响因素。结果:HPS组血浆sST2、IL-33水平高于感染组和健康组,感染组血浆sST2、IL-33水平高于健康组(P<0.05)。sST2、IL-33及二者联合诊断HPS的AUC分别为0.848、0.857、0.942。死亡组铁蛋白、sST2、IL-33高于存活组,白细胞计数(WBC)低于存活组(P<0.05)。sST2、IL-33是HPS患儿死亡的独立危险因素(P<0.05)。sST2、IL-33及二者联合预测HPS患儿死亡的AUC分别为0.862、0.838、0.952。结论:血浆sST2、IL-33水平检测可能是诊断儿童HPS的重要方法,且二者对于预测HPS患儿死亡有重要参考价值。
Objective:To explore the diagnostic and prognostic value of plasma suppression of tumorigenicity 2(sST2)and interleukin-33(IL-33)in children with hemophagocytic syndrome(HPS).Methods:From June 2019 to September 2022,30 children with HPS admitted to our hospital were regarded as the HPS group,and their clinical data and laboratory indicators were recorded.They were grouped into a survival group of 20 cases and a mortality group of 10 cases based on survival outcomes;30 infected children excluded from HPS were as the infection group;meantime,30 healthy children who underwent outpatient physical examinations were as the health group.Enzyme linked immunosorbent assay(ELISA)was applied to detect plasma levels of sST2 and IL-33;the diagnostic and prognostic values of plasma levels of sST2 and IL-33 for HPS were analyzed using the receiver operating characteristic;and logistic multivariate regression was applied to analyze the influencing factors of prognosis in children with HPS.Results:The plasma levels of sST2 and IL-33 in the HPS group were higher than those in the infected and healthy groups,while the plasma levels of sST2 and IL-33 in the infected group were higher than those in the healthy group(P<0.05).The AUC for diagnosing HPS with sST2,IL-33,and their combination was 0.848,0.857,and 0.942,respectively.Ferritin,sST2,IL-33 in mortality group were higher than those in survival group,while WBC was lower than that in survival group(P<0.05).sST2 and IL-33 were independent risk factors for mortality in children with HPS(P<0.05).The AUC of sST2,IL-33,and their combination in predicting mortality in HPS children were 0.862,0.838,and 0.952,respectively.Conclusion:The detection of plasma levels of sST2 and IL-33 may be an important method for diagnosing HPS in children,and both have important reference value for predicting mortality in children with HPS.
作者
李妍
刘炜
张合成
周建文
刘云婧
刘俊闪
郭战萍
LI Yan;LIU Wei;ZHANG Hecheng(Department of Hematology Research Laboratory(He’nan Provincial Key Laboratory of Pediatric Hematology),Children’s Hospital Affiliated to Zhengzhou University,He’nan Children’s Hospital,Zhengzhou Children’s Hospital,Zhengzhou City,He’nan Province 450018;不详)
出处
《医学理论与实践》
2024年第21期3619-3622,共4页
The Journal of Medical Theory and Practice
基金
河南省医学科技攻关计划联合共建项目(LHGJ20220726)。
