摘要
目的分析沙利度胺治疗口腔黏膜疾病所致不良反应的类别、特征、临床症状,为患者安全用药提供参考依据。方法采用横断面研究,回顾性分析解放军空军军医大学第三附属医院2019年1月至2023年12月报告的44例沙利度胺药品不良反应报告,对不良反应发生年龄与性别的相关性、发生时间与性别相关性、不良反应累及器官及附件、不良反应转归等进行统计分析。结果该院沙利度胺不良反应发生率为0.21%(44/21329),以女性患者居多。50.00%(22/44)的不良反应累及多个器官,但相对较为集中,以皮肤及其附件、中枢及外周神经系统、胃肠道系统为主,主要表现为皮疹、头晕等。结论沙利度胺使用过程中应密切监测其不良反应,尤其是对神经系统的损害,针对育龄期人群,应高度关注其潜在的致畸性,同时也应当不断探索拓宽监测渠道,提升患者居家用药安全。
Objective To analyze the categories,characteristics,and clinical symptoms of adverse reactions associated with thalidomide treatment for oral mucosal diseases,providing a reference for the safe use of this medication in patients.Methods A cross-sectional study was conducted to retrospectively analyze the adverse reactions to thalidomide treatment in 44 patients with oral mucosal diseases who received treatment at the Third Affiliated Hospital of Air Force Medical University from January 2019 to December 2023.The correlation between the age and sex of patients experiencing adverse reactions,the timing of these reactions in relation to sex,the organs and their appendages affected by the adverse reactions,and the outcomes of these reactions were statistically analyzed.Results The incidence of adverse reactions associated with thalidomide treatment at the hospital was 0.21%(44/21329),with a higher prevalence among female patients.Multiple organs were affected in 50.00%(22/44)of the cases,though the reactions were relatively concentrated,primarily involving the skin and its appendages,the central and peripheral nervous systems,and the gastrointestinal system.The main manifestations included rash and dizziness.Conclusion In the treatment of oral mucosal diseases with thalidomide,it is essential to monitor adverse drug reactions,particularly those affecting the nervous system.Special attention should be given to the potential teratogenicity of thalidomide in individuals of childbearing age.In addition,it is vital to consistently investigate strategies to ensure the safety of patients using medication at home.
作者
薛晓娟
黄静
冯斌
王维刚
岳姣
马棪斐
林瑶
Xue Xiaojuan;Huang Jing;Feng Bin;Wang Weigang;Yue Jiao;Ma Yanfei;Lin Yao(Department of Pharmacy,The Third Affiliated Hospital of Air Force Medical University,National Clinical Research Center for Oral Diseases,Xi'an 710032,Shaanxi Province,China)
出处
《中国基层医药》
CAS
2024年第10期1457-1462,共6页
Chinese Journal of Primary Medicine and Pharmacy
基金
国家口腔疾病临床医学研究中心项目(LCC202207)。
关键词
口腔黏膜
口腔疾病
药物相关性副作用和不良反应
药物副反应报告系统
药物监测
沙利度胺
Mouth mucosa
Mouth diseases
Drug-related side effects and adverse reactions
Adverse drug reaction reporting systems
Drug monitoring
Salidomide
