摘要
目的探讨补肺息喘方结合常规西药治疗慢性阻塞性肺疾病(COPD)稳定期(肺脾气虚证)患者的效果及对肺功能和免疫功能的影响。方法本研究纳入2021年8月至2023年1月在河南大学第一附属医院就诊的100例COPD稳定期(肺脾气虚证)患者,以随机数字表法分成观察组和对照组。对照组接受乌美溴铵维兰特罗吸入粉雾剂治疗,观察组在此基础上联合补肺息喘方治疗,均治疗2个月。观察两组临床疗效、中医肺脾气虚证证候积分、COPD患者自我评估测试量表(CAT)评分、6 min步行测试(6MWT)、改良英国医学研究学会呼吸困难指数量表(mMRC)评分、肺功能指标[第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC]、免疫功能指标[CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)]水平和不良反应。结果治疗2个月后,观察组总有效率、6MWT、FEV_(1)、FVC、FEV_(1)/FVC、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组(P<0.05),肺脾气虚证证候积分、CAT评分、mMRC评分、CD8^(+)低于对照组(P<0.05),两组均未发生与治疗药物相关的不良反应事件。结论补肺息喘方结合常规西药治疗COPD稳定期(肺脾气虚证)的效果显著,能够有效缓解临床症状,减轻呼吸困难程度,提高活动耐力,改善机体免疫功能,安全有效。
Objective To explore the therapeutic effect of the combination of Bufei Xichuan Prescription and conventional Western medicine on stable chronic obstructive pulmonary disease(COPD)(lung spleen qi deficiency syndrome)patients and its impact on lung function and immune function.Methods This study included 100 patients with stable COPD(lung spleen qi deficiency syndrome)who visited the First Affiliated Hospital of Henan University from August 2021 to January 2023.They were divided into an observation group and a control group using a random number table method.The control group received treatment with inhaled powder mist of Umetam Bromide and Valantro,while the observation group was treated with a combination of Bufei Xichuan Prescription on this basis for 2 months.The clinical efficacy,the score of traditional Chinese medicine lung spleen qi deficiency syndrome,COPD assessment test(CAT)score,6 minute walking test(6MWT),modified Medical Research Council(mMRC)score,lung function indicators[forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC),FEV_(1)/FVC],and immune function indicator[CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)]levels,and adverse reactions of two groups were observed.Results After 2 months of treatment,the total effective rate,6MWT,FEV_(1),FVC,FEV_(1)/FVC,CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in the observation group were higher than those in the control group(P<0.05),while the syndrome score,CAT score,mMRC score,and CD8^(+)in the lung spleen deficiency syndrome group were lower than those in the control group(P<0.05).Both groups did not experience any adverse reactions related to the treatment drugs.Conclusion The combination of Bufei Xichuan Prescription and conventional Western medicine has a significant therapeutic effect on stable COPD(lung spleen qi deficiency syndrome)patients,which can effectively alleviate clinical symptoms,reduce respiratory distress,improve activity endurance,improve immune function,and is safe and effective.
作者
王红燕
陈高瑛
齐红松
WANG Hongyan;CHEN Gaoying;QI Hongsong(The First Affiliated Hospital of Henan University,Kaifeng 475000,China)
出处
《河南医学研究》
CAS
2024年第20期3776-3780,共5页
Henan Medical Research
关键词
慢性阻塞性肺疾病
稳定期
肺脾气虚证
补肺息喘方
chronic obstructive pulmonary disease
stable period
lung spleen qi deficiency syndrome
Bufei Xichuan Prescription
