摘要
肝细胞癌(HCC)具有复杂的生物学特性、高度的异质性和免疫抑制肿瘤微环境,预后差。代谢重编程(MR)是肿瘤细胞最重要的特征之一,脂质MR已成为HCC生长和转移的重要机制。本文综述了常见的脂质及其代谢相关分子与HCC发生、发展的关系,以期为HCC的治疗提供新的分子靶点。
Hepatocellular carcinoma(HCC)has complex biological characteristics,highly heterogeneous property and immunosuppressive tumor microenvironment.HCC carries a dismal prognosis.Metabolic reprogramming(MR)is one of the most important features of tumor cells and the lipid metabolism has been an important mechanism underlying HCC growth and metastasis.In this article,we review the roles of common lipid and its metabolism-related molecules in carcinogenesis of HCC and provides new targets for therapy of HCC.
作者
李晓斌
刘博文(综述)
胡世平(审校)
Li Xiaobin;Liu Bowen;Hu shiping(Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《实用肝脏病杂志》
CAS
2024年第6期957-960,共4页
Journal of Practical Hepatology
基金
国家自然科学基金面上项目(编号:81973733)
深圳市科技计划项目(编号:JCYJ20220530172812028)
深圳市龙岗医疗卫生科技创新计划项目(编号:LGKCYLWS2021000015)
深圳市龙岗区医疗卫生技术攻关项目(编号:LGKCYLWS2022006)。
关键词
HCC
脂质代谢
MR
靶点
Hepatocellular carcinoma
Lipid metabolism
Metabolic reprogramming
Carcinogenesis
Targets
