摘要
目的探讨武汉市黄陂区老年人血清尿酸/肌酐比值(UA/Cr)与代谢综合征(MS)的相关性。方法本研究为横断面研究,于2018年1至12月,采用方便抽样法,选取武汉市黄陂区居住的35838名≥65岁的体检人群作为研究对象,为其提供免费健康体检项目,收集一般资料、体格检查和实验室检查等资料。根据UA/Cr水平的四分位数将研究对象分为Q1~Q4组,采用中华医学会糖尿病学分会制定的标准诊断MS。采用Spearman相关分析和多因素logistic回归分析UA/Cr与MS的相关性;采用限制性立方样条回归模型评估UA/Cr水平与MS的关联强度剂量-反应关系。结果武汉市黄陂区老年人MS的检出率为21.94%(7863/35838)。Spearman相关性分析显示,老年人UA/Cr与腰围(r=0.188)、空腹血糖(FPG)(r=0.024)、收缩压(r=0.019)和甘油三酯(TG)(r=0.209)呈正相关(均P<0.05),与高密度脂蛋白胆固醇(HDL-C)(r=-0.035)呈负相关(P<0.05),与舒张压无明显相关性(P=0.263)。多因素logistic回归分析显示,调整年龄、性别、锻炼、吸烟和饮酒后,与UA/Cr的Q1组相比,Q2组(OR=1.20,95%CI:1.11~1.29)、Q3组(OR=1.52,95%CI:1.41~1.64)和Q4组(OR=2.22,95%CI:2.07~2.39)MS患病风险增加(均P<0.05)。按性别分层后,男性Q3组和Q4组MS患病风险增加,分别为Q1组的1.27、1.68倍(均P<0.05),女性Q2组、Q3组和Q4组MS患病风险增加,分别为Q1组的1.30、1.72和2.64倍(均P<0.05)。限制性立方样条回归模型表明,UA/Cr水平与MS患病风险呈非线性剂量-反应关系(P非线性<0.05),当UA/Cr>4.56时,MS患病风险随UA/Cr水平升高而增加。结论武汉市黄陂区老年人UA/Cr水平与MS患病风险呈正向关联,不同性别老年人的UA/Cr水平与MS患病风险之间存在差异。
Objective To explore the correlation between serum uric acid to creatinine ratio(UA/Cr)and metabolic syndrome(MS)in elderly population in Huangpi District,Wuhan City.Methods A cross-sectional study.From January to December in 2018,a total of 45619 elderly people aged 65 years and above living in Huangpi District,Wuhan City were recruited as the research subjects by convenience sampling.A free physical examination program was provided to the subjects;and the general information,physical and laboratory examination data were collected.According to the quartiles of UA/Cr levels,the subjects were divided into 4 groups(Q1-Q4 groups),and MS was diagnosed according to the criteria developed by the Chinese Diabetes Society.Spearman correlation analysis and multivariate logistic regression were used to analyze the correlation between UA/Cr and MS in those subjects.The dose-response relationship between UA/Cr and MS was evaluated by a restricted cubic spline regression model.Results The detection rate of MS in the elderly population in Huangpi District,Wuhan City was 21.94%(7863/35838).The results of Spearman correlation analysis showed that UA/Cr was positively correlated with waist circumference(r=0.188),fasting plasma glucose(FPG)(r=0.024),systolic blood pressure(SBP)(r=0.019)and triglyceride(TG)(r=0.209)in elderly people(all P<0.05),and negatively correlated with high-density lipoprotein cholesterol(HDL-C)(r=-0.035)(P<0.05).However,no correlation between UA/Cr and diastolic blood pressure(DBP)was found(P=0.263).Multivariate logistic regression analysis showed that,after adjusting for age,gender,exercise,smoking,and alcohol drinking,compared with UA/Cr group Q1,the risk of MS in group Q2(OR=1.20,95%CI:1.11-1.29),group Q3(OR=1.52,95%CI:1.41-1.64)and group Q4(OR=2.22,95%CI:2.07-2.39)were all increased significantly(all P<0.05).After gender stratification,in the male,the risk of MS in group Q3 and group Q4 was 1.27 and 1.68 times of that in group Q1,respectively(both P<0.05);and in the female,the risk of MS in group Q2,Q3 and Q4 was 1.30,1.72 and 2.64 times of that in group Q1,respectively(all P<0.05).The restrictive cubic spline regression model indicated that the level of UA/Cr had a non-linear dose-response relationship with the risk of MS(P nonlinear<0.05).When UA/Cr>4.56,the risk of MS increased with the increase of UA/Cr level.Conclusions The UA/Cr is positively correlated with the risk of MS in elderly population in Huangpi District,Wuhan City.There are differences between the UA/Cr level and the risk of MS in the elderly of different genders.
作者
武瑞燕
魏沨
顾文勇
刘晴
Wu Ruiyan;Wei Feng;Gu Wenyong;Liu Qing(Department of Epidemiology and Health Statistics,School of Public Health,Wuhan University,Wuhan 430071,China;Huangpi District Center for Disease Control and Prevention,Wuhan 430300,China;Department of Prevention and Control of Chronic Diseases,Huangpi District Center for Disease Control and Prevention,Wuhan 430300,China)
出处
《中华健康管理学杂志》
CAS
CSCD
北大核心
2024年第10期747-753,共7页
Chinese Journal of Health Management
基金
武汉市卫生健康科研基金(WY22A06)。
关键词
老年人
尿酸
肌酐
代谢综合征X
Aged
Uric acid
Creatinine
Metabolic syndrome X
