摘要
目的通过评估全身免疫炎症指数(systemic immune inflammatory index,SII)水平与系统性红斑狼疮(systemic lupus erythematosus,SLE)患者的疾病活动度之间的关系,探索SLE患者疾病活动度简便评估的新方法;方法收集在昆明医科大学第一附属医院风湿免疫科就诊的SLE患者临床资料,根据系统性红斑狼疮活动指数(SLEDAI)分组,比较、分析SII水平与疾病活动的相关性,绘制接受者工作特征曲线(receiver operating characteristic curve,ROC),评价SII对SLE疾病活动度的预测价值。结果SLE患者疾病轻度活动组的SII水平显著低于重度活动组(经Bonferroni校正,P<0.05/3=0.017),SII水平与SLEDAI评分存在相关性(r=0.130,P<0.05),ROC曲线下面积为0.581(P<0.05)。结论SII可作为反映SLE疾病活动度的一种简便、快速的参考指标。
Objective To explore a new method for assessing disease activity in patients with systemic lupus erythematosus(SLE)by evaluating the relationship between the level of the systemic immune-inflammatory index(SII)and disease activity in SLE patients.Methods Clinical data of SLE patients who treated in the Department of Rheumatology and Immunology of First Affiliated Hospital of Kunming Medical University were collected.Patients were grouped based on the Systemic Lupus Erythematosus Disease Activity Index(SLEDAI).The correlation between SII level and disease activity was compared and analyzed,and Receiver operating characteristic curve(ROC)was plotted to evaluate the predictive value of SII for SLE disease activity.Results The SII levels in the mild active group of SLE patients were significantly lower than that in the severe active group(Bonferroni correction,P<0.05/3=0.017).There was a correlation between SII levels and SLEDAI scores(r=0.130,P<0.05),with an area under the ROC curve of 0.581(P<0.05).Conclusion SII can serve as a simple and quick reference indicator for reflecting disease activity in SLE.
作者
沈枫
杨一帆
白茹
李姝
刘爽
徐健
SHEN Feng;YANG Yifan;BAI Ru;LI Shu;LIU Shuang;XU Jian(Dept.of Rheumatology and Immunology,1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032;Dept.of Critical Care Medicine,Kaiyuan People’s Hospital,Kaiyuan Honghe 661699,China)
出处
《昆明医科大学学报》
CAS
2024年第10期45-49,共5页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(32270947
81760296)
云南省高层次卫生技术人才(领军人才)培养项目(L-2019004)
云南省“万人计划”名医人才专项(YNWR-MY-2018-040)
云南省皮肤免疫性疾病临床医学中心项目(ZX2019-03-02)
风湿免疫性疾病多中心临床科研转化平台项目(2018ZF016)。
关键词
系统性红斑狼疮
全身免疫炎症指数
系统性红斑狼疮活动指数
Systemic lupus erythematosus
Systemic immune inflammatory index
Systemic lupus erythematosus activity index
