摘要
目的:探究健脾益肾通络汤治疗IgA肾病效果及对患者肾功能、炎症因子的影响。方法:选取IgA肾病患者98例,采用随机掷硬币法分为两组。西药组常规西药治疗,49例,联合组在西药组的基础上服用健脾益肾通络汤,49例。治疗3个月后比较两组疗效、中医证候积分、肾功能[24 h尿蛋白定量(24 h UTP)、血清血肌酐(SCr)、血尿素氮(BUN)、白蛋白(ALB)]、炎症因子[肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、干扰素-γ(INF-γ)]和不良反应。结果:治疗总有效率联合组为95.92%,高于西药组的81.63%(P<0.05)。治疗后两组的中医证候积分、24 h UTP及血清SCr、BUN、IL-6、TNF-α均降低,且联合组均低于西药组,差异有统计学意义(均P<0.05)。治疗后,两组患者血清ALB、INF-γ均升高,且联合组高于西药组,差异有统计学意义(均P<0.05)。不良反应总发生率西药组为10.20%,联合组为14.29%,两组比较差异无统计学意义(P>0.05)。结论:健脾益肾通络汤治疗IgA肾病疗效较好,可以有效减轻患者临床症状,改善肾功能,降低炎症反应,安全性较高。
Objective:To explore effect of Jianpi Yishen Tongluo decoction in treatment of IgA nephropathy and its influence on renal function and inflammatory factors.Methods:98 patients with IgA nephropathy were divided into western medicine group(conventional western medicine treatment,49 cases)and joint group(Jianpi Yishen Tongluo decoction on the basis of western medicine group,49 cases)by random coin tossing method.After 3 months of treatment,efficacy,TCM syndromes scores,renal function[24 h urinary total protein(24 h UTP),serum creatinine(SCr),blood urea nitrogen(BUN),albumin(ALB)],inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interferon-γ(INF-γ)]and adverse reactions were compared.Results:The total response rate was 95.92%,which was higher than 81.63%in the western medicine group(P<0.05).After treatment,the TCM syndromes scores and levels of 24 h UTP and serum SCr,BUN,TNF-αand IL-6 in the two groups were decreased,and the scores and levels in joint group were lower than those in western medicine group,difference statistically significant(all P<0.05).The levels of serum ALB and INF-γwere increased in both groups after treatment,and the levels were higher in joint group than those in western medicine group,difference statistically significant(all P<0.05).The total incidence of adverse reactions was 10.20%in the western medicine group and 14.29%in the combined group,with no significant difference between the two groups(P>0.05).Conclusion:Jianpi Yishen Tongluo decoction has significant efficacy in the treatment of IgA nephropathy,and can effectively relieve clinical symptoms,improve renal functionand reduce inflammatory response,with high safety.
作者
唐晨思
向广生
张翠娜
赵晶晶
路博宇
TANG Chensi;XIANG Guangsheng;ZHANG Cuina;ZHAO Jingjing;LU Boyu(Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050031,China)
出处
《陕西中医》
CAS
2024年第11期1499-1503,共5页
Shaanxi Journal of Traditional Chinese Medicine
基金
河北省中医药管理局科研计划项目(2019407)。
关键词
IGA肾病
健脾益肾通络汤
中医证候积分
肾功能
炎症因子
不良反应
IgA nephropathy
Jianpi Yishen Tongluo decoction
Traditional Chinese medicine syndrome points
Renal function
Inflammatory factors
Untoward effect
