摘要
近年大量研究证实中性粒细胞(N)通过多种途径诱发类风湿性关节炎(RA)的炎症反应,造成不同程度的关节破坏。调节N已成为防治RA的重要途径。中医药是“国宝”,除了传统抗风湿药、昂贵的生物制剂外,多种中药有效成分、单味药、中药复方和中医外治法均可调节N产生或合成的细胞因子、趋化因子、蛋白酶、活性氧及中性粒细胞胞外诱捕网,改善RA病情进展。故从N在RA中作用机制及基于这些机制的靶向中医药在RA的治疗展开探讨,为临床研究RA提供参考。
In recent years,a large number of studies have confirmed that neutrophil(N)can induce inflammatory response of rheumatoid arthritis(RA)through various ways,then cause different degrees of joint destruction.Therefore,regulating N has become an important way to prevent and treat RA.Traditional Chinese medicine is a“national treasure”.In addition to traditional anti-rheumatic drugs and expensive biologics,variety of effective ingredients of traditional Chinese medicine,single medicine,compound Chinese medicine and external Chinese medicine therapy can regulate N productionor synthesis of cytokines,chemokines,proteases,reactive oxygen species and neutrophil extracellular trapping nets,then improve progression of RA disease.Therefore,mechanism of action of N in RA and targeted traditional Chinese medicine based on these mechanisms in treatment of RA,in order to provide reference for clinical research on RA.
作者
代雨晴
熊浪
唐芳
马武开
兰维娅
蒋总
涂海霞
蔡珊燕
DAI Yuqing;XIONG Lang;TANG Fang;MA Wukai;LAN Weiya;JIANG Zong;TU Haixia;CAI Shanyan(Guizhou University of Traditional Chinese Medicine,Guiyang 550002,China)
出处
《陕西中医》
CAS
2024年第11期1576-1578,F0003,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(82160917)
贵州省科学技术厅科研项目[黔科合基础-ZK(2023)一般435]
贵州省大学生创新创业训练计划项目(202110662031)
贵州省高等学校中西医结合防治疾病转化医学重点实验室项目[黔教技(2023)017号]
贵州中医药大学国家与省级科技创新人才团队培育项目[贵中医TD合字(2022)004号]。
关键词
类风湿性关节炎
炎症反应
中医外治疗法
中性粒细胞
中性粒细胞胞外诱捕网
Rheumatoid arthritis
Inflammatory response
External treatment of Chinese medicine
Neutrophils
Neutrophil extracellular trapping net
