摘要
目的探讨微波消融辅助下肝切除术治疗原发性肝癌患者的临床疗效。方法根据治疗方法的不同将60例原发性肝癌患者分为肝切除组(n=30,传统肝切除术)和消融组(n=30,微波消融辅助下肝切除术)。比较两组患者的手术相关指标、肝功能指标[丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、白蛋白(ALB)]、并发症发生情况及预后。结果消融组患者的术中出血量明显少于肝切除组,输血率明显低于肝切除组,手术时间、术后住院时间均明显短于肝切除组,差异均有统计学意义(P﹤0.01)。术后1个月,两组患者ALT、AST水平均高于本组术前,ALB水平均低于本组术前,消融组患者ALT、AST水平均低于肝切除组,ALB水平高于肝切除组,差异均有统计学意义(P﹤0.05)。两组患者的并发症总发生率比较,差异无统计学意义(P﹥0.05)。消融组患者的1年生存率高于肝切除组,1年复发率低于肝切除组,差异均有统计学意义(P﹤0.05)。结论与传统肝切除术相比,微波消融辅助下肝切除术治疗原发性肝癌患者,可减少术中出血量,缩短术后住院时间,改善患者预后,对肝功能影响更小,且不增加并发症。
Objective To explore the clinical efficacy of microwave ablation assisted hepatectomy in the treatment of patients with primary liver cancer.Method According to different treatment methods,60 patients with primary liver cancer were divided into hepatectomy group(n=30,traditional hepatectomy)and ablation group(n=30,microwave ablation assisted hepatectomy).The operation related indexes,liver function indexes[alanine aminotransferase(ALT),aspartate aminotransferase(AST),albumin(ALB)],complications and prognosis were compared between the two groups.Result The intraoperative blood loss in ablation group was significantly less than that in hepatectomy group,the blood transfusion rate was significantly lower than that in hepatectomy group,and the operation time and postoperative hospital stay were significantly shorter than those in hepatectomy group,and the differences were statistically significant(P<0.01).One month after surgery,the ALT and AST levels in both groups were higher than those before surgery,the ALB levels were lower than those before surgery,the ALT and AST levels in ablation group were lower than those in hepatectomy group,the ALB level was higher than that in hepatectomy group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of complications between the two groups(P>0.05).The 1-year survival rate in ablation group was higher than that in hepatectomy group,and the 1-year recurrence rate was lower than that in hepatectomy group,and the differences were statistically significant(P<0.05).Conclusion Compared with traditional hepatectomy,microwave ablation assisted hepatectomy in the treatment of primary liver cancer patients can reduce intraoperative blood loss,shorten postoperative hospital stay,improve patient prognosis,have less impact on liver function,and do not increase complications.
作者
卢致洋
蔡联明
廖宝春
刘振华
王博文
LU Zhiyang;CAI Lianming;LIAO Baochun;LIU Zhenhua;WANG Bowen(Department of Abdominal Surgery,Ganzhou Cancer Hospital,Ganzhou 341000,Jiangxi,China)
出处
《癌症进展》
2024年第18期2028-2030,2035,共4页
Oncology Progress
基金
江西省卫生健康委科技计划项目(202212548)。
关键词
原发性肝癌
微波消融
肝切除术
肝功能
预后
primary liver cancer
microwave ablation
hepatectomy
liver function
prognosis
