摘要
目的分析深髓静脉(deep medullary vein,DMV)评分在评估脑小血管病(cerebral small vessel disease,CSVD)患者认知功能障碍方面的应用价值。方法收集2022年5月至2023年12月就诊于浙江中医药大学附属丽水中医院的108例患者的临床及影像学资料。根据简易精神状态评估量表将患者分为认知功能障碍组(36例)和认知功能正常组(72例)。在磁敏感图像上根据两侧额叶、顶叶、枕叶6个区域的DMV可视情况分别评分0~3分,6个区域的评分总和为DMV评分(0~18分)。应用国际CSVD指南评估患者的CSVD负荷。分析DMV评分和认知功能障碍的相关性,比较DMV评分、CSVD评分对认知功能障碍的诊断价值。结果108例患者的CSVD负荷评分为1(0,2)分,DMV评分为4(1,9)分。DMV评分和是否存在认知功能障碍呈正相关(r=0.525,P<0.001)。认知功能障碍组和认知功能正常组的年龄、脑微出血、血管周围间隙扩大、脑白质高信号、CSVD负荷及DMV评分差异有统计学意义(P<0.05)。DMV评分诊断认知功能障碍的受试者操作特征曲线下面积为0.820(95%CI:0.741~0.898,P<0.001)。结论DMV评分与CSVD认知功能障碍之间存在正相关关系,且对认知功能障碍具有一定的预测价值。
Objective To explore the diagnostic value of deep medullary vein(DMV)score for cognitive impairment in patients with cerebral small vessel disease(CSVD).Methods Collect clinical and imaging data of 108 patients who visited Lishui Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University from May 2022 to December 2023.According to the mini-mental state examination,patients were divided into a cognitive impairment group(36 cases)and a cognitive function normal group(72 cases).On magnetic sensitive images,the DMV scores of the six regions on both sides of the frontal lobe,parietal lobe,occipital lobe are rated from 0 to 3 points based on their visual conditions,and the total scores of the six regions is the DMV score(0 to 18 points).Applying international CSVD guidelines to assess CSVD burden in patients.Analyze the correlation between DMV score and cognitive impairment,and compare the diagnostic value of DMV scores and CSVD score for cognitive impairment.Results The median CSVD burden score of 108 patients was 1(0,2)points,and the median DMV score was 4(1,9)points.The DMV score was positively correlated with the presence of cognitive impairment(r=0.525,P<0.001).There were statistically significant differences in age,cerebral microbleeds,perivascular space enlargement,white matter hyperintensities,CSVD burden,and DMV score between the cognitive impairment group and the cognitive function normal group(P<0.05).The area under the receiver operating characteristic curve of diagnosed with cognitive impairment using DMV score was 0.820(95%CI:0.741-0.898,P<0.001).Conclusion DMV score is positively correlated with CSVD cognitive impairment,and it has certain predictive value for cognitive impairment.
作者
汪庆春
徐世达
蓝海源
雷新军
WANG Qingchun;XU Shida;LAN Haiyuan;LEI Xinjun(Department of Radiology,Lishui Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University,Lishui 323000,Zhejiang,China)
出处
《中国现代医生》
2024年第30期37-41,共5页
China Modern Doctor
基金
浙江省中医药科技计划项目(2024ZL1284)。
关键词
深髓静脉
认知功能障碍
脑小血管病
磁共振成像
Deep medullary vein
Cognitive impairment
Cerebral small vessel disease
Magnetic resonance imaging
