摘要
血小板减少是肝移植术后常见的并发症之一,其病理生理机制包括血小板生成不足、血小板消耗增多等,严重影响肝移植受者的预后。肝移植术前肝炎病毒感染、术中缺血损伤、术后使用免疫抑制药等多种因素都可能导致肝移植术后血小板减少,尽早发现和有效治疗肝移植术后血小板减少是目前的研究热点。本文结合现有文献资料,从血小板减少的定义、病理生理机制、危险因素、治疗及预防等方面展开综述,探讨肝移植术后血小板减少发生发展及相关诊治策略,旨在优化现有治疗方案,降低移植术后血小板减少发生的风险,改善肝移植受者预后。
Thrombocytopenia is one of the common complications after liver transplantation,withpathophysiological mechanisms including insufficient platelet production and increased platelet consumption,whichseverely affects the prognosis of liver transplant recipients.Various factors such as preoperative hepatitis virus infection,intraoperative ischemic injury,and postoperative use of immunosuppressive drugs may lead to thrombocytopenia afterliver transplantation.Early detection and effective treatment of thrombocytopenia after liver transplantation are currentlyhot topics of research.Based on the existing literature,this article reviews the definition,pathophysiological mechanisms,risk factors,treatment,and prevention of thrombocytopenia,and discusses the occurrence and development ofthrombocytopenia after liver transplantation and related diagnosis and treatment strategies,aiming to optimize the existingtreatment opinions,reduce the risk of thrombocytopenia after transplantation and improve the prognosis of liver transplantrecipients.
作者
蔡涛
曹经琳
窦剑
曾强
Cai Tao;Cao Jinglin;Dou Jian;Zeng Qiang(Department of Hepatobiliary Surgery,the Third Hospital of Hebei Medical University,Shijiazhuang 050051,China)
出处
《器官移植》
CAS
CSCD
北大核心
2024年第6期964-969,共6页
Organ Transplantation
基金
河北省政府资助临床医学优秀人才项目(ZF2024083)。
关键词
血小板减少
肝移植
血小板生成素
血管性血友病因子裂解蛋白酶13
脾功能亢进
边缘供者
感染
免疫抑制药
Thrombocytopenia
Liver Transplantation
Thrombopoietin
A disintegrin and metalloproteinasewith thrombospondin type 1 motifs 13
Hypersplenism
Marginal Donor
Infection
Immunosuppressive drug
