摘要
肺动脉高压(pulmonary arterial hypertension,PAH)是一种恶性进展性肺血管疾病,特征是肺动脉周围炎症和肺动脉重塑,与多种心血管和呼吸系统等疾病有关,发病机制尚不明确。日益增多的证据表明PAH患者具有独特的肠道菌群组成,肠道菌群及其代谢产物在PAH的发生与发展中发挥重要作用。本文将综述肠道菌群及其代谢物在PAH发病中的作用,介绍基于肠道菌群及代谢物的新兴治疗方法(如粪便微生物移植、益生菌、补充短链脂肪酸)的研究进展。
Pulmonary arterial hypertension(PAH)is a malignant progressive pulmonary vascular disease characterized by perivascu-lar inflammation and pulmonary artery remodeling and is associated with various cardiovascular and respiratory diseases,with an un-clear pathogenesis.Increasing evidence indicates that patients with PAH have a distinct composition of gut microbiota,and gut micro-biota and its metabolites play a crucial role in the development and progression of PAH.This article reviews the role of gut microbiota and its metabolites in the pathogenesis of PAH and introduces the research advances in emerging therapies based on gut microbiota and its metabolites,such as fecal microbiota transplantation,probiotics,and supplementation of short-chain fatty acids.
作者
常开丽
张灿
卢祥婷
戴海龙
Chang Kaili;Zhang Can;Lu Xiangting;Dai Hailong(Key Laboratory of Cardiovascular Disease of Yunnan Province,Clinical Medicine Center for Cardiovascular Disease of Yunnan Province,Department of Cardiology,Yan'an Hospital Affiliated to Kunming Medical University)
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2024年第10期1039-1044,共6页
Journal of Chongqing Medical University
基金
国家自然科学基金资助项目(编号:82060018、81700438)
云南省科技计划资助项目(编号:202301AY070001-300、202101AS070043、202102AA310003-7、202105AF150019)。
关键词
肺动脉高压
肠道微生物
肠道菌群代谢物
pulmonary arterial hypertension
gut microbiota
gut microbiota metabolites
