摘要
目的:评估5种中成药与常规西药联合治疗成人变应性鼻炎的临床疗效。窗体顶端方法:采用计算机对中国知网、中国生物医学文献服务系统、万方数据库、维普数据库、PubMed、Embase、Web of Science和the Cochrane Library等8个数据库进行检索,检索时间为建库至2024年2月21日,纳入鼻渊通窍颗粒、玉屏风颗粒、通窍鼻炎颗粒(胶囊)、鼻炎康片、香菊胶囊治疗成人变应性鼻炎的中文或英文随机对照试验(RCT)。运用Stata 16软件实施网状Meta分析,并使用Risk of bias 2工具辅助获得风险偏倚图。结果:最终纳入106篇RCT文献,样本量为11966例,其中观察组(在常规西药的基础上联合应用上述5种特定中成药之一)5996例,对照组(常规西药治疗)5970例。网状Meta分析结果表明,在提高临床总有效率方面,鼻炎康片+常规西药治疗表现出最佳的临床效果;在降低血清免疫学指标(免疫球蛋白E)方面,玉屏风颗粒+常规西药的临床效果最佳。结论:当前证据表明,在常规西药的基础上联合不同中成药治疗成人变应性鼻炎的疗效更好,但考虑纳入文献质量参差不齐,为了进一步验证该结论,未来需要开展更多大规模、高质量、多元化的RCT。
OBJECTIVE:To evaluate the clinical efficacy of five kinds of Chinese patent medicine combined with conventional Western medicine in the treatment of allergic rhinitis(AR)in adults.METHODS:Chinese or English randomized controlled trials(RCTs)on Biyuan Tongqiao granules,Yupingfeng granules,Tongqiao Biyan granules(capsules),Biyankang tablets,Xiangju capsules in the treatment of AR in adults were retrieved from CNKI,SinoMed,Wanfang Data,VIP,PubMed,Embase,Web of Science and the Cochrane Library databases,the searching time was from base-building to Feb.21st,2024.The Stata 16 software was used to perform network Meta-analysis,Risk of bias 2 was used to gain the risk of bias map.RESULTS:A total of 106 RCTs were enrolled,with a sample size of 11966,including 5996 cases in the observation group(given one of the above 5 specific kinds of Chinese patent medicine based on conventional Western medicine)and 5970 cases in the control group(conventional Western medicine).Results of network Meta-analysis indicated that in terms of improving the clinical total effective rate,Biyankang tablets+conventional Western medicine treatment showed the best clinical effect.In terms of reducing serum immunological indicators(immunoglobulin E),Yupingfeng granules+conventional Western medicine showed the best clinical effect.CONCLUSIONS:Current evidence suggests that different Chinese patent medicine in combination with conventional Western medicines has better efficacy in the treatment of AR in adults.Due to the uneven quality of the enrolled studies,more large-scale,high-quality and diversified RCTs are needed in the future to further validate this conclusion.
作者
徐佳琪
王睦天
谢云雪
张新轶
郭小静
赵启亮
孙宏源
刘旻
XU Jiaqi;WANG Mutian;XIE Yunxue;ZHANG Xinyi;GUO Xiaojing;ZHAO Qiliang;SUN Hongyuan;LIU Min(Dept.of Infectious Diseases,the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;National Clinical Research Center for Traditional Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China;Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《中国医院用药评价与分析》
2024年第10期1239-1246,共8页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
天津市科技人才培育项目(No.KJ20205)。
关键词
变应性鼻炎
成人
中成药
网状Meta分析
Allergic rhinitis
Adults
Chinese patent medicine
Network Meta-analysis
