摘要
目的:观察纤维蛋白原(FIB)、D-二聚体(D-D)水平联合检测在慢性阻塞性肺疾病急性加重期(AECOPD)患者细菌感染诊断中的效能。方法:回顾性分析2021年2月至2023年6月该院收治的120例AECOPD患者的临床资料,根据痰培养结果将其分为细菌感染组63例(并依据预后将其分为预后良好患者和预后不良患者)、非细菌感染组57例,另选取同期该院60名健康体检者为对照组。比较三组及不同预后细菌感染AECOPD患者FIB、D-D水平,绘制受试者工作特征(ROC)曲线,分析FIB、D-D水平单项及联合检测在AECOPD患者细菌感染诊断中的效能。结果:细菌感染组FIB、D-D水平均高于非细菌感染组和对照组,且非细菌感染组高于对照组,差异有统计学意义(P<0.05);预后不良患者FIB、D-D水平均高于预后良好患者,差异有统计学意义(P<0.05);ROC曲线分析结果显示,FIB、D-D水平单项及联合检测诊断AECOPD患者细菌感染的曲线下面积(AUC)分别为0.724、0.698、0.905,其中联合检测诊断AECOPD患者细菌感染的AUC大于二者单项检测。结论:FIB、D-D水平联合检测诊断AECOPD患者细菌感染的效能高于二者单项检测。
Objective:To observe efficiency of combined detection of fibrinogen(FIB)and D-dimer(D-D)levels in diagnosis of bacterial infection in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:The clinical data of 120 patients with AECOPD admitted to the hospital from February 2021 to June 2023 were retrospectively analyzed.According to the results of sputum culture,they were divided into bacterial infection group(63 cases,then were divided into the patients with good prognosis and the patients with poor prognosis according to prognosis)and non-bacterial infection group(57 cases).In addition,60 healthy subjects in the hospital during the same period were selected as the control group.The levels of FIB and D-D were compared among the three groups and the AECOPD patients with bacterial infection with different prognosis.The receiver operating characteristic(ROC)curve was drawn to analyze the efficiencies of single and combined detection of FIB and D-D levels in the diagnosis of bacterial infection in the AECOPD patients.Results:The levels of FIB and D-D in the bacterial infection group were higher than those in the non-bacterial infection group and the control group,those in the non-bacterial infection group were higher than those in the control group,and the differences were statistically significant(P<0.05).The FIB and D-D levels in the patients with poor prognosis were higher than those in the patients with good prognosis,and the differences were statistically significant(P<0.05).The ROC curve analysis showed that the area under the curve(AUC)of single and combined detection of FIB and D-D levels in the diagnosis of bacterial infection in the AECOPD patients was 0.724,0.698 and 0.905,respectively.The AUC of combined detection in the diagnosis of bacterial infection in the AECOPD patients was biger than that of single detection.Conclusions:The efficiency of combined detection of FIB and D-D levels in the diagnosis of bacterial infection in AECOPD patients is higher than that of single detection.
作者
刘海波
LIU Haibo(Department of Clinical Laboratory of Zhengzhou Hospital of Traditional Chinese Medicine,Zhengzhou 450007 Henan,China)
出处
《中国民康医学》
2024年第21期127-129,共3页
Medical Journal of Chinese People’s Health
关键词
慢性阻塞性肺疾病急性加重期
纤维蛋白原
D-二聚体
细菌感染
检测
诊断
Acute exacerbation of chronic obstructive pulmonary disease
Fibrinogen
D-dimer
Bacterial infection
Detection
Diagnosis
