摘要
目的 探讨血清成纤维细胞生长因子2(FGF2)和成纤维细胞生长因子受体1(FGFR1)与子痫前期(PE)患者妊娠结局的关系。方法 选取2021年1月—2022年12月河南省妇幼保健院PE患者82例(PE组)和健康孕妇82名(健康对照组)。收集所有研究对象的临床资料,并检测血清FGF2和FGFR1水平。根据PE患者的妊娠结局分为结局良好组(44例)和结局不良组(38例)。采用Pearson相关分析评估PE患者血清FGF2与FGFR1的相关性。采用Logistic回归分析评估PE患者发生不良妊娠结局的影响因素。采用受试者工作特征(ROC)曲线评价血清FGF2和FGFR1判断PE患者发生不良妊娠结局的效能。结果 PE组血清FGF2和FGFR1水平均低于健康对照组(P<0.05)。结局不良组血清FGF2和FGFR1水平均低于结局良好组(P<0.05),早发型PE和重度PE所占比例高于结局良好组(P<0.05),其他临床资料2个组之间差异均无统计学意义(P>0.05)。PE患者血清FGF2与FGFR1呈正相关(r=0.524,P<0.05)。早发型PE、重度PE是PE患者发生不良妊娠结局的危险因素[比值比(OR)值分别为3.682、4.029,95%可信区间(CI)分别为1.054~12.858、1.086~14.951,P<0.05],FGF2、FGFR1升高为保护因素(OR值分别为0.491、0.586,95%CI分别为0.293~0.822、0.382~0.898,P<0.05)。血清FGF2、FGFR1单项检测和联合检测判断PE患者发生不良妊娠结局的曲线下面积(AUC)分别为0.81、0.82、0.92。结论 PE患者血清FGF2和FGFR1水平显著降低,2项指标联合检测对PE患者发生不良妊娠结局有较高的预测效能。
Objective To investigate the relationship between the expression of serumfibroblast growth factor 2(FGF2)andfibroblast growth factor receptor 1(FGFR1)and pregnancy outcome in patients with preeclampsia(PE).Methods Totally,82 PE patients diagnosed in Maternal and Child Health Hospital of Henan Province from January 2021 to December 2022 were enrolled as study subjects,which included 44 cases of good outcome and 38 cases of adverse outcome,and another 82 pregnant females with successful delivery were enrolled as healthy control group.Serum FGF2 and FGFR1 levels were determined.The correlation of FGF2 and FGFR1 was analyzed by Pearson analysis.The influencing factors of adverse pregnancy outcome in PE patients were analyzed by Logistic regression analysis.The predictive values of serum FGF2 and FGFR1 on adverse pregnancy outcome in PE patients was evaluated by receiver operating characteristic(ROC)curve.Results Serum FGF2 and FGFR1 levels were higher in healthy control group than in PE group(P<0.05),and serum FGF2 and FGFR1 levels in adverse outcome group were lower than those in good outcome group(P<0.05).The percentages of early PE and severe PE in adverse outcome group were higher than those in good outcome group(P<0.05).There was no statistical significance for the other clinical data between the 2 groups(P>0.05).FGF2 was positively correlated with FGFR1 in PE group(r=0.524,P<0.05).Both early PE[odds ratio(OR)=3.682,95%confidence interval(CI)1.054-12.858]and severe PE(OR=4.029,95%CI 1.086-14.951)were risk factors for adverse pregnancy outcome in PE patients(P<0.05),and increased FGF2(OR=0.491,95%CI 0.293-0.822)and increased FGFR1(OR=0.586,95%CI 0.382-0.898)were protective factors(P<0.05).The areas under curves(AUC)for the single and combined determinations of serum FGF2 and FGFR1 for adverse pregnancy outcome in patients with PE were 0.81,0.82 and 0.92,respectively.Conclusions The levels of serum FGF2 and FGFR1 of PE patients with adverse outcome are lower than those of patients with good outcome,and the combined determination has good predictive value of adverse pregnancy outcome in PE patients.
作者
张彩丽
罗晓华
杨培峰
刘鹏丽
任方
ZHANG Caili;LUO Xiaohua;YANG Peifeng;LIU Pengli;REN Fang(Department Obstetrics and Gynecology,the Third Affiliated Hospital of Zhengzhou University,Maternal and Child Health Hospital of Henan Province,Zhengzhou 450001,Henan,China)
出处
《检验医学》
CAS
2024年第10期945-949,共5页
Laboratory Medicine
基金
河南省科技攻关计划项目(212102310473)。
