摘要
目的回顾性探讨我国区域性宫颈鳞癌患者中人乳头瘤病毒(HPV)感染型别排序、年龄段分布、老年女性HPV感染特点及临床意义。方法收集1978年11月至2024年1月河南省信阳市商城县人民医院、南京中医药大学附属南京中医院、江苏省南京明基医院、南京同仁医院、南京市妇幼保健院等53家医院病理科的3101例病理组织学诊断为宫颈鳞癌的患者。从宫颈鳞癌石蜡组织中提取HPVDNA,采用聚合酶链式反应结合基因芯片法对3101例患者宫颈鳞癌组织进行23种HPV分型检测,并对HPV致癌风险型别的排序、≥60岁的老年女性和不同年龄段患者HPV型别分布情况进行分析。结果3101例宫颈鳞癌患者中检测出HPV感染者2879例(92.84%),其中单一型别的HPV感染者2460例(79.33%)。排名前8位单一型别高危HPV型别依次是16型、18型、58型、31型、33型、52型、59型、45型。其中16型感染人数比18型高(P<0.05),58型感染人数比31型明显增高(P<0.05),52型感染人数比59型明显增高(P<0.05)。40~49岁和50~59岁患者中患病人数、HPV感染人数、单一型别16型及18型感染人数均排名前两位。≥60岁的老年女性占宫颈鳞癌患者的30.44%。结论将HPV16、18、58型和HPV31、33、52、59型及其他HPV型别分别列为高风险、中风险和低风险致癌组,便于宫颈病变的分层管理。要重视对40~59岁年龄段女性的筛查工作,加强≥60岁老年女性宫颈鳞癌的筛查力度。
Objective The aim of this article is to retrospectively explore the human papillomavirus(HPV)infection in pa‐tients with cervical squamous cell carcinoma in central-eastern China,with focus on the types,age distribution,specific characteristics of HIV infection in elderly women and its clinical significance.Methods From November 1978 to January 2024,3101 patients di‐agnosed as cervical squamous cell carcinoma by histopathology were collected from the Pathology Departments of 53 hospitals,includ‐ing People’s Hospital of Shangcheng County in Xinyang,Henan Province,Nanjing Traditional Chinese Medicine Hospital affiliated with Nanjing University of Chinese Medicine,Nanjing Mingji Hospital in Jiangsu Province,Nanjing Tong Ren Hospital,and Nanjing Maternal and Child Health Care Hospital.HPV DNA was extracted from the cervical squamous cell carcinoma paraffin tissue.Poly‐merase chain reaction combined with gene chip technology was used to classify and analyze 23 kinds of HPV.The study analyzed the ranking of HPV carcinogenic risk types,and the distribution of HPV types among elderly patients aged 60 and older,as well as across different age groups.Results Out of 3101 patients with cervical squamous cell carcinoma,2879(92.84%)were found to be infect‐ed with HPV,of which 2460(79.33%)were infected with single-type of HPV.The top eight high-risk HPV types in terms of frequen‐cy were HPV-16、HPV-18、HPV-58、HPV-31、HPV-33、HPV-52、HPV-59 and HPV-45.The number of patients with HPV-16 were higher than those with HPV-18(P<0.05),patients with HPV-58 was significantly higher than those with HPV-31(P<0.05)and pa‐tients with HPV-52 was significantly higher than those with HPV-59(P<0.05).In the age groups of 40-49 years and 50-59 years,the number of patients,HPV infections,and single-type of HPV-16 and HPV-18 were in the top two.Elderly women aged 60 and older ac‐counted for 30.44%.Conclusion To facilitate the stratified management of cervical lesions,we suggest to classify HPV-16,18 and 58 as the high-risk carcinogenic group,HPV-31,33,52 and 59 as the medium-risk carcinogenic group,and other types as the low-risk group.The screening of women aged 40~59 years old should be emphasized,and the screening for cervical squamous cell carcinoma in elderly women aged 60 and older should be strengthened.
作者
朱贤海
黄健
耿建祥
丁康
兰建云
叶梅
王志蕙
韩春荣
王德望
季月霞
ZHU Xianhai;HUANG Jian;GENG Jianxiang;DING Kang;LAN Jianyun;YE Mei;WANG Zhihui;HAN Chun‐rong;WANG Dewang;JI Yuexia(Department of Pathology,the People's Hospital of Shangcheng County of Henan Province,Shangcheng 465316,Henan,China;Shanghai Centre of Systems Biomedicine,Shanghai Jiao Tong University,Shanghai 200240,China;Department of Pathology,Nanjing Transitional Chinese Medical Hospital Affliated to Nanjing University of Chinese Medicine,Nanjing 210022,Jiangsu,China;Anorectal De-partment,Nanjing Transitional Chinese Medical Hospital Af-fliated to Nanjing University of Chinese Medicine,Nanjing 210022,Jiangsu,China;Department of Pathology,the First People's Hospital of Yancheng City of Jiangsu Prov-ince,Yancheng 224006,Jiangsu,China;Department of Gynaecology,Maternal and Child Health Hospital of Jiangn-ing Region of Nanjing City,Nanjing 211199,Jiangsu,China;Department of Pathology,the Tumor Hospital of Linyi City of Shandong Province,Linyi 276034,Shandong,China;Department of Pathology,the People's Hospital of Lishui Region of Nanjing City,Nanjing 211200,Jiangsu,China;Department of Pathology,the First Hospital of Dongguan Af-fliated to Guangdong Medical University,Dongguan 523059,Guangdong,China;Department of Pathology,Hos-pital of Traditional Chinese Medicine of Changshu City of Jiangsu Province,Changshu 215500,Jiangsu,China)
出处
《医学研究与战创伤救治》
CAS
北大核心
2024年第8期824-829,共6页
Journal of Medical Research & Combat Trauma Care
基金
江苏省南京市卫健委中医支助项目(2009-92)
常熟市卫健委科技计划项目(CSWS202021)。
关键词
宫颈
鳞状细胞癌
人乳头瘤病毒
型别
年龄
排序
cervix
squamous cell carcinoma
human papillomavirus
type
age
seqencing
