摘要
人类免疫缺陷病毒-1型(HIV-1)特有的逆转录酶无校正功能,使其成为变异最快的病毒之一,并在全球流行中进化出众多亚型和亚簇。不同HIV-1毒株有着独特生物学差异和致病力变化,在传播特征趋势中仍在不断演化,不利于防控部门把握病毒流行和致病力变异的完整信息,因而难以制定针对性的干预工作。鉴于此,应开展全方位毒株亚型致病性特征研究,揭示病毒适应性进化同毒力水平之间的关系,明确各亚型遗传特征及异质性对毒株致病性的影响,并获得HIV-1基因和表型变异完整数据,以提高艾滋病的总体防控效果。本文重点总结了HIV-1亚型表型特征、毒力水平和对抗病毒治疗后免疫重建的影响。
The unique reverse transcriptase of human immunodeficiency virus-1(HIV-1)has no proofreading function,making it one of the fastest-mutating viruses and evolving into numerous subtypes and subclusters during the global epidemic.Different HIV-1 strains have unique biological differences and changes in pathogenicity and are still evolving in transmission characteristics.This is very unfavorable for prevention and control departments to grasp complete information on the prevalence and pathogenicity of the virus,making it difficult to formulate targeted intervention work.In view of this,it is necessary to carry out comprehensive research on the pathogenic characteristics of virus strain subtypes,reveal the relationship between the adaptive evolution of the virus and the virulence level,clarify the impact of the genetic characteristics and heterogeneity of each subtype on the pathogenicity of the virus strain,and obtain complete data on HIV-1 genetic and phenotypic variations so as to improve the overall prevention and control effect of AIDS.This article focuses on summarizing the phenotypic characteristics of HIV-1 subtypes,virulence levels and the impact of immune reconstitution after antiviral therapy.
作者
李康
邵一鸣
LI Kang;SHAO Yiming(School of Basic Medical Sciences,Guangxi Medical University,Nanning 530021,China;Chinese Center for Disease Control and Prevention,Beijing 102200,China;Changping Laboratory,Beijing 102200,China;State Key Laboratory of Diagnosis and Treatment of Infectious Diseases,the First Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310000,China)
出处
《广西医科大学学报》
CAS
2024年第10期1345-1352,共8页
Journal of Guangxi Medical University
基金
国家自然科学基金资助项目(No.81861138011)
国家科技部重点研发计划项目(No.2022YFC2305201)。
