摘要
目的探究钙卫蛋白、细胞因子样蛋白1(CYTL1)对老年膝骨关节炎(knee osteoarthritis,KOA)患者的诊断价值。方法选取2019年8月-2023年8月在常州市第一人民医院诊治的老年KOA患者65例作为研究组,选取同时期在本院进行健康体检的65例作为对照组。通过Pearson法分析相关性;Logistic回归分析影响老年KOA发生的因素;受试者工作特征(ROC)曲线分析血清钙卫蛋白、CYTL1水平对老年KOA发生的诊断价值。结果研究组血清钙卫蛋白、TNF-α、CRP、B细胞百分比水平显著高于对照组(P<0.05),CYTL1、IL-4、CD3^(+)T细胞百分比、CD4^(+)T细胞百分比、CD8+T细胞百分比水平显著低于对照组(P<0.05)。随着老年KOA患者病情加重,血清钙卫蛋白水平显著升高(P<0.05),CYTL1水平显著降低(P<0.05)。老年KOA患者中血清钙卫蛋白水平与CYTL1水平呈负相关(r=-0.672,P<0.05)。钙卫蛋白、TNF-α、B细胞百分比是影响老年KOA患者发生的危险因素(P<0.05),CYTL1、IL-4是影响老年KOA患者发生的保护因素(P<0.05)。血清钙卫蛋白、CYTL1二者联合诊断老年KOA发生的曲线下面积(AUC)为0.865、0.850、0.926,二者联合明显高于钙卫蛋白、CYTL1单独诊断(Z_(二者联合-钙卫蛋白)=2.018,Z_(二者联合-CYTL1)=2.514,P<0.05)。结论老年KOA患者血清钙卫蛋白水平升高,CYTL1水平降低,对老年KOA的诊断有临床价值。
Objective To explore the diagnostic value of calprotectin and cytokine like protein 1(CYTL1)in elderly knee osteoarthritis(KOA).Methods A total of 65 elderly KOA patients diagnosed and treated in our hospital from August 2019 to August 2023 were collected as the study group.Sixty-five patients who underwent health examination in our hospital were as the control group.Pearson method was used for analyzing correlation.Logistic regression was applied to analyze the factors affecting the occurrence of elderly KOA.Receiver operating characteristic(ROC)curve was applied to analyze the diagnostic value of serum calprotectin and CYTL1 levels for the occurrence of elderly KOA.Results The serum levels of calprotectin,TNF-α,CRP,and percentage of B cells in the study group were obviously higher than those in the control group(P<0.05).The levels of CYTL1,IL-4,percentage of CD3^(+)T cells,percentage of CD4^(+)T cells,and percentage of CD8+T cells in the control group were obviously lower than those in the control group(P<0.05).As the condition of elderly KOA patients worsened,serum calprotectin level obviously increased(P<0.05),while CYTL1 level obviously decreased(P<0.05).There was a negative correlation between serum calprotectin level and CYTL1 level in elderly KOA patients(r=-0.672,P<0.05).Calprotectin,TNF-α,and percentage of B cells were risk factors affecting the occurrence of elderly KOA patients(P<0.05).CYTL1 and IL-4 were protective factors affecting the occurrence of elderly KOA patients(P<0.05).The area under the curve(AUC)of serum calprotectin,CYTL1,and their combination in the diagnosis of elderly KOA was 0.865,0.850,and 0.926,respectively.The combination of the two was obviously higher than that of calprotectin and CYTL1 alone(Z_(combination-calprotectin)=2.018,Z_(combination-CYTL1)=2.514,P<0.05).Conclusion The serum calprotectin level increases and CYTL1 level decreases in elderly patients with KOA,which has clinical value for the diagnosis of elderly KOA.
作者
马冰沁
朱春晖
周维波
何俊波
MA Bingqin;ZHU Chunhui;ZHOU Weibo;HE Junbo(Department of General Medicine,the First People’s Hospital of Changzhou,Changzhou 213003,China;Department of Orthopedics,the Second People’s Hospital of Changzhou Affiliated to Nanjing Medical University,Changzhou 213003,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2024年第11期1617-1621,共5页
Chinese Journal of Osteoporosis
基金
常州市科技计划资助项目(CJ20230057)。
