摘要
文章旨在探究葛根提取物对不同炎症动物模型的干预作用,从而为开发新型抗炎药提供思路。实验采用二甲苯诱导耳肿胀炎症模型,角叉菜胶诱导足肿胀炎症模型,分别观察耳肿胀度或足肿胀度。与空白组相比,模型组的肿胀率均较高,说明造模均成功。在耳肿胀实验中,阳性药品给药组和葛根提取液给药组的肿胀抑制率分别为62.92%和66.69%;在足肿胀实验中,阳性药品给药组和葛根提取液给药组的肿胀抑制率分别为60.77%和63.77%。结果表明,小鼠急性耳肿胀和足肿胀炎症模型方法可靠,阳性药品给药组和葛根提取液给药组的肿胀抑制率均较好,说明葛根具有抗炎抑制作用,为葛根提取物的进一步开发和应用提供了理论依据。
To provide ideas for the development of novel anti-inflammatory drugs,this article investigated the interventional effects of pueraria extract on different animal models of inflammation.A model of xylene-induced ear swelling inflammation and a model of carrageenan-induced foot swelling inflammation were constructed to observe the ear swelling or foot swelling.In the experiment of ear swelling and foot swelling,the swelling rate of the model groups was higher than that of the blank group,indicating that the modeling was successful.In the ear swelling experiment,the swelling inhibition rates of the positive drug administration group and the pueraria extract administration group were 62.92%and 66.69%,respectively.In the foot swelling experiment,the swelling inhibition rates of the positive drug administration group and the pueraria extract administration group were 60.77%and 63.77%,respectively.It indicated that the model method of acute ear swelling and foot swelling inflammation in mice was reliable.The swelling inhibition rates were good in the positive drug administration group and the pueraria extract administration group,which indicated that pueraria had the anti-inflammatory inhibition effect and provided a theoretical basis for the further development and applications of pueraria.
作者
马美杰
任丽
郭润发
冯爽
MA Meijie;REN Li;GUO Runfa;FENG Shuang(School of Pharmaceutical and Chemical Engineering,Zhengzhou University of Industrial Application Technology,Zhengzhou 450000,China;Henan Natural Drug Quality Control and Production Process Research Center,Zhengzhou 450000,China)
出处
《工业微生物》
CAS
2024年第5期1-3,共3页
Industrial Microbiology
基金
2023年郑州工业应用技术学院重点科研项目“后疫情时代药学服务需求及供给研究”(编号:2023ZD010)
郑州工业应用技术学院“药学服务思政样板课程”郑工政[2023]264号
郑州工业应用技术学院“药学服务专创融合特色示范课程”郑工政[2024]39号。
关键词
葛根
炎症模型
耳肿胀
足肿胀
pueraria
inflammation model
ear swelling
foot swelling
