摘要
目的探究逐瘀泻热汤治疗对重症胰腺炎患者血清胃肠激素、肠黏膜功能及免疫功能的影响。方法选取2020年4月—2021年7月河北省中医院收治的重症胰腺炎患者124例进行研究。并以随机数字表法将124例患者平均分为两组(观察组、对照组),对照组(62例)采用常规西医治疗(常规对症治疗、醋酸奥曲肽注射液、贝酯、奥美拉唑钠),观察组(62例)在对照组基础上加用逐瘀泻热汤治疗,两组均治疗14 d。数据比较:疗效与中医证候积分、血清胃肠激素、肠黏膜功能及免疫功能、不良反应情况。结果治疗14 d后,观察组患者APACHEⅡ评分及中医证候积分均低于对照组,胃动素(motilin,MTL)、胆囊收缩素(cholecystokinin,CCK)水平高于对照组,D-乳酸、二胺氧化酶(diamine oxidase,DAO)、内毒素及尿乳果糖/甘露醇(lactulose,L/mannitol,M)值低于对照组,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平高于对照组,CD+8水平低于对照组,全血黏度比、血浆黏度比、血栓长度、血小板黏附率低于对照组(P<0.05);对照组1例呕吐、1例腹泻,观察组1例乏力,两组不良反应比较差异无统计学意义(P>0.05)。结论逐瘀泻热汤治疗对重症胰腺炎患者疗效显著,可明显改善血清胃肠激素水平,保护肠黏膜功能及免疫功能,有利于患者预后,且用药安全可靠。
Objective To investigate the effects of Zhuyu Xiere Decoction(逐瘀泻热汤)on serum gastrointestinal hormones,intestinal mucosal function and immune function in patients with severe pancreatitis.Methods A total of 124 patients with severe pancreatitis admitted to the department of Hebei Provincial Hospital of Traditional Chinese Medicine from April 2020 to July 2021 were selected for this study.And with the random number table method,the patients were divided into two groups(observation group and the control group).The control group(62 cases)were treated with conventional western medicine treatment(conventional symptomatic treatment,Octreotide Acetate Injection,bei ester,omeprazole sodium).The observation group(62 cases)added Zhuyu Xiere Decoction based on the basis of control group.Two groups were treated 14 d.The curative effect and TCM syndrome scores,serum gastrointestinal hormone,intestinal mucosal function and immune function and adverse reactions of two groups were compared.Results After 14 days of treatment,Acute Physiology and Chronic Health Evaluation(APACHE)Ⅱscore and TCM syndrome scores of the observation group were lower than those of the control group.The levels of motilin(MTL)and cholecystokinin(CCK)were higher than those of the control group.The values of D-lactic acid,diamine oxidase(DAO),endotoxin and L/M were lower than those of the control group.The levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)were higher than those of the control group and the CD84 level was lower than that of the control group.The whole blood viscosity ratio,plasma viscosity ratio,thrombus length and platelet adhesion rate were lower than those of control group(P<0.05).There was 1 case of vomiting and 1 case of diarrhea in the control group,and 1 case of fatigue in the observation group.Conclusion Zhuyu Xiere Decoction has a significant therapeutic effect on patients with severe pancreatitis,and can significantly improve the levels of serum gastrointestinal hormones,protect intestinal mucosal function and immune function,and is beneficial to the prognosis of patients,and the medica tion is safe and reliable.
作者
王雷
耿艳娜
申立静
董旭
刘源
WANG Lei;GENG Yanna;SHEN Lijing;DONG Xu;LIU Yuan(Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang 050013,Hebei,China)
出处
《中华中医药学刊》
CAS
2024年第11期210-213,共4页
Chinese Archives of Traditional Chinese Medicine
基金
河北省中医药管理局科研计划项目(2021025)
河北中医学院科技能力提升项目(2019016)。
关键词
逐瘀泻热汤
重症胰腺炎
血清胃肠激素
肠黏膜功能
免疫功能
Zhuyu Xiere Decoction(逐瘀泻热汤)
severe pancreatitis
serum gastrointestinal hormone
intestinal mucosal function
immune function
