摘要
目的:探讨首都儿科研究所附属儿童医院(以下简称“我院”)血液科患儿药品不良反应(ADR)的发生特点与规律,为血液相关疾病的儿童用药安全提供参考。方法:统计和分析2022-2023年我院血液科143例ADR报告,包括给药途径、药品种类、临床表现、ADR类型及转归等。结果:143例ADR报告中,静脉滴注是占比最高的给药途径(74.82%)。发生ADR的药品种类中,免疫抑制剂的ADR发生率最高(44.06%),其次为抗肿瘤药(40.56%)、抗感染药(11.19%)。103例患儿好转(72.03%)。3例(2.10%)为严重ADR。相关性评价为肯定的有12例(8.39%),很可能为81例(56.64%),可能为50例(34.97%)。结论:临床应加强对ADR的认知和管理,做好ADR监测,鼓励多学科临床工作人员积极参与ADR管理,减少ADR发生率,保障儿童用药安全。
Objective:To probe into the occurrence characteristics and regularity of adverse drug reactions(ADR)in children in the Hematology Department of Children’s Hospital,Capital Institute of Pediatrics(hereinafter referred to as“our hospital”),so as to provide reference for the medication safety in children with hematology-related diseases.Methods:Statistics and analysis were made on 143 ADR reports from the Hematology Department of our hospital from 2022 to 2023,including the route of administration,types of drugs,clinical manifestations,ADR types and outcomes.Results:Among 143 ADR reports,intravenous infusion was the most common route of administration(74.82%).Immunosuppressive drugs had the highest incidence of ADR(44.06%),followed by anti-tumor drugs(40.56%)and anti-infective drugs(11.19%).Totally 103 cases showed improvement(72.03%).There were 3 cases(2.10%)of severe ADR.The correlation was evaluated as positive in 12 cases(8.39%),likely in 81 cases(56.64%)and possible in 50 cases(34.97%).Conclusion:Clinics should strengthen the knowledge and management of ADR and pay attention to the ADR monitoring,and encourage multidisciplinary clinical staff to actively participate into the management of ADR,so as to reduce the occurrence of ADR and ensure the medication safety of children.
作者
崔颖
钟旭丽
刘碧晴
张建民
Cui Ying;Zhong Xuli;Liu Biqing;Zhang Jianmin(Children’s Hospital,Capital Institute of Pediatrics,Beijing 100020,China)
出处
《儿科药学杂志》
CAS
2024年第11期26-29,共4页
Journal of Pediatric Pharmacy
关键词
血液
药品不良反应
儿童
影响因素
监护
hematology
adverse drug reactions
children
influencing factors
guardianship
