摘要
目的观察左乙拉西坦联合奥卡西平治疗小儿部分性发作癫痫对患儿认知能力及脑电图指标的影响。方法选取2023年3月—2024年5月永州市第三人民医院收治的部分性发作癫痫患儿82例,采用随机数字表法分为观察组和对照组,各41例。对照组单纯予奥卡西平片治疗,观察组在对照组基础上联合左乙拉西坦口服溶液治疗,2组均连续治疗18周。比较2组治疗效果,治疗前及治疗18周后脑电图指标(δ、θ、α、β波段的相对功率)、认知功能[智商(FIQ)、操作智商(PIQ)、言语智商(VIQ)]变化及不良反应。结果观察组患儿治疗总有效率为95.12%,高于对照组的73.17%(χ^(2)=7.405,P=0.007);治疗18周后,2组α、β波段相对功率及FIQ、PIQ、VIQ评分均较治疗前升高,δ、θ波段相对功率较治疗前降低,且观察组高/低于对照组(P均<0.05);观察组与对照组不良反应总发生率(24.39%vs.19.51%)比较差异无统计学意义(χ^(2)=0.285,P=0.594)。结论左乙拉西坦联合奥卡西平治疗小儿部分性发作癫痫效果肯定,对患儿认知能力及脑电图指标均有积极影响,且安全性较高。
Objective To observe the effects of levetiracetam combined with oxcarbazepine on cognitive function and electroencephalographic indices in children with partial-onset epilepsy.Methods Eighty-two pediatric patients with partial-onset epilepsy admitted to the Third People′s Hospital of Yongzhou City from March 2023 to May 2024 were randomly divided into observation group and control group(n=41 per group)using a random number table.The control group received monotherapy with oxcarbazepine tablets,while the observation group received additional levetiracetam oral solution.Both groups were treated for 18 consecutive weeks.The therapeutic effects,changes in electroencephalographic indices(relative power ofδ,θ,αandβbands)and cognitive function(FIQ,PIQ and VIQ)before and after 18 weeks of treatment,as well as adverse events,were compared between the two groups.Results The overall effective rate was significantly higher in the observation group(95.12%)compared to the control group(73.17%)(χ^(2)=7.405,P=0.007).After 18 weeks of treatment,both groups showed increased relative power in theαandβbands,as well as improved scores in FIQ,PIQ and VIQ compared to baseline.Conversely,the relative power in theδandθbands decreased.The observation group exhibited higher or lower values compared to the control group in these measures(all P<0.05).There was no significant difference in the overall incidence of adverse events between the observation group(24.39%)and the control group(19.51%)(χ^(2)=0.285,P=0.594).Conclusion The combination of levetiracetam and oxcarbazepine demonstrated significant efficacy in treating pediatric partial-onset epilepsy,with positive impacts on both cognitive function and electroencephalographic indices.Moreover,this treatment regimen exhibited a favorable safety profile.
作者
王禄艳
郭太勇
吕芳露
WANG Luyan;GUO Taiyong;LYU Fanglu(The Third People′s Hospital of Yongzhou City,Hunan Province,Yongzhou 425000,China)
出处
《临床合理用药杂志》
2024年第31期1-4,共4页
Chinese Journal of Clinical Rational Drug Use
基金
国家自然科学基金(818002621)。
关键词
小儿癫痫
左乙拉西坦
奥卡西平
认知能力
脑电图
治疗效果
Pediatric epilepsy
Levetiracetam
Oxcarbazepine
Cognitive function
Electroencephalographic indices
Therapeutic efficacy
