摘要
In the development of colorectal cancer(CRC),cancer-associatedfibroblasts(CAFs)play a pivotal role in establishing tumor-permissive extracellular matrix structures,angiogenesis,and modulating the immune status of the tumor microenvironment(TME),thereby influencing tumor metastasis and resistance to radiotherapy and chemotherapy.The pleiotropic effects of CAFs in the TME may be attributed to the heterogeneous origin and high plasticity of their population.Given the specificity of CAFs,they provide a variety of potential target molecules for future CRC treatment,which may play an indispensable role in CRC therapeutic strategies.This review summarizes the origin of CAFs and their roles in the CRC tumor microenvironment,including the interaction between exosomes and CAFs in CRC.Additionally,we discuss potential therapeutic strategies targeting CAFs.
出处
《BIOCELL》
SCIE
2024年第11期1569-1578,共10页
生物细胞（英文）
基金
supported by grants fromthe National Natural Science Foundation of China (No.30870971)
Major Program of NSFC (No. 81090420)
National Natural Science Foundation of Zhejiang(LY17H160017, LY12H16027).
