摘要
心血管疾病(cardiovascular diseases,CVD)是我国居民死亡的首要原因,严重影响患者的生存质量。CVD病理机制较为复杂,以慢性低度炎症为主要特征。核苷酸结合寡聚化结构域样受体蛋白3(nucleotide-binding oligomerization domain-like receptor protein 3,NLRP3)炎症小体是调控炎症反应的关键因子,在固有免疫应答中发挥重要作用。其异常活化诱导的过度炎症反应和细胞焦亡与动脉粥样硬化、心肌梗死和糖尿病心肌病等多种CVD发生发展密切相关。近年来研究表明,运动作为一种安全有效的非药物干预手段,可通过抑制NLRP3炎症小体活化来减轻心血管炎症反应和细胞焦亡,从而在CVD防治中发挥积极作用。但当前对于运动介导NLRP3炎症小体防治CVD的理论及机制仍缺乏系统阐释。因此,本文综述了NLRP3炎症小体与CVD的关系,探讨了不同运动类型、强度和持续时间对NLRP3炎症小体活化的影响,并总结分析以NLRP3炎症小体为靶点进行运动干预防治CVD所涉及的相关信号通路,以期为运动防治CVD提供新的思路和参考。
Cardiovascular diseases(CVD)are the leading cause of death among residents in China and significantly impact patients’quality of life.The pathogenesis of CVD is complex,with chronic low-grade inflammation as a predominant feature.The nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome is a key regulator of inflammatory responses and plays a crucial role in innate immune responses.Its abnormal activation leads to excessive inflammation and pyroptosis,which is closely associated with the development of atherosclerosis,myocardial infarction,diabetic cardiomyopathy,and other CVDs.Recent studies suggest that exercise,as a safe and effective non-pharmacological intervention,can mitigate cardiovascular inflammation and pyroptosis by inhibiting NLRP3 inflammasome activation,thereby playing a positive role in CVD prevention and treatment.However,the theories and mechanisms of exercise-mediated NLRP3 inflammasome intervention in CVD remain underexplored.Therefore,this review summarizes the relationship between the NLRP3 inflammasome and CVD,explores the effects of different types,intensities,and durations of exercise on NLRP3 inflammasome activation,and provides a comprehensive analysis of the signaling pathways involved in exercise interventions targeting the NLRP3 inflammasome for the prevention and treatment of CVD.The aim is to provide new insights and references for exercise-based prevention and management of CVD.
作者
陈俊
贾绍辉
薛新轩
CHEN Jun;JIA Shao-Hui;XUE Xin-Xuan(School of Graduate of Wuhan Sports University,Wuhan 430079,China;Hubei Key Laboratory of Sport Training and Monitoring,School of Sports Medicine of Wuhan Sports University,Wuhan 430079,China;School of Sports Training of Wuhan Sports University,Physical Fitness Training Teaching and Research Section,Wuhan 430079,China)
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2024年第11期1493-1503,共11页
Chinese Journal of Biochemistry and Molecular Biology
基金
湖北省教育厅科学研究计划项目(No.B2019193)资助。
关键词
核苷酸结合寡聚化结构域样受体蛋白3
炎症小体
运动
心血管疾病
炎症
细胞焦亡
nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)
inflammasome
exercise
cardiovascular diseases(CVD)
inflammation
pyroptosis
