摘要
目的探讨冠心病合并高尿酸血症(HUA)患者叉头转录因子O亚家族成员3a(FOXO3a)、核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)、可溶性细胞间黏附分子1(sICAM-1)水平变化的意义。方法选取河南科技大学第一附属医院2021年1月至2022年8月收治的156例冠心病患者为研究对象,根据尿酸水平分为HUA组(62例)和UA正常组(94例)。比较两组一般临床资料及FOXO3a、NLRP3、sICAM-1水平,分析FOXO3a、NLRP3、sICAM-1水平与临床资料中有统计学差异指标及UA水平相关性,采用logistic回归分析影响冠心病合并HUA的危险因素,以受试者工作特征(ROC)曲线分析FOXO3a、NLRP3、sICAM-1水平联合检测对冠心病合并HUA的诊断价值。结果HUA组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平高于UA正常组(P<0.05);HUA组FOXO3a、NLRP3、sICAM-1水平高于UA正常组(P<0.05);相关性分析发现,FOXO3a、NLRP3、sICAM-1水平与TC、TG、LDL-C、UA水平均呈正相关(P<0.05);logistic回归分析发现,TC(>5.04 mmol·L^(-1))、TG(>1.88 mmol·L^(-1))、LDL-C(>2.53 mmol·L^(-1))、FOXO3a(>4.65μg·L^(-1))、sICAM-1(>195.73μg·L^(-1))、NLRP3(>1322.12 ng·L^(-1))水平是冠心病患者合并HUA的危险因素(P<0.05);ROC分析发现,FOXO3a、sICAM-1、NLRP3水平联合诊断冠心病合并HUA的曲线下面积(AUC)为0.811,敏感度、特异度分别为95.16%、67.02%,优于各指标单一指标诊断,具有较高诊断效能(P<0.05)。结论FOXO3a、NLRP3、sICAM-1参与冠心病合并HUA发生过程,且在临床诊断冠心病合并HUA方面具有较高效能。
Objective To explore the significance of changes in the levels of forkhead transcription factor O subfamily member 3a(FOXO3a),NLR family pyrin domain containing 3(NLRP3)and soluble intercellular adhesion molecule-1(sICAM-1)in patients with coronary heart disease complicated with hyperuricemia(HUA).Methods A total of 156 patients with coronary heart disease admitted to the First Affiliated Hospital of Henan University of Science and Technology from January 2021 to August 2022 were selected as research objects,and were divided into HUA group(62 cases)and UA normal group(94 cases)according to uric acid level.Compared the general clinical data and levels of FOXO3a,NLRP3,and sICAM-1 between two groups,and analyzed the differences between FOXO3a,NLRP3,and sICAM-1 levels and indicators with statistical differences in clinical data,as well as the correlation between UA levels,logistic regression analysis was used to analyze the risk factors of coronary heart disease combined with HUA.The diagnostic value of combined detection of FOXO3a,NLRP3,and sICAM-1 levels in coronary heart disease combined with HUA was analyzed using the receiver operating characteristic(ROC)curve.Results The levels of total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)in HUA group were higher than those in UA normal group(P<0.05).The levels of FOXO3a,NLRP3,and sICAM-1 in the HUA group were higher than those in the UA normal group(P<0.05).Correlation analysis found that the levels of FOXO3a,NLRP3,and sICAM-1 were positively correlated with the levels of TC,TG,LDL-C,and UA(P<0.05).Logistic regression analysis found that levels of TC(>5.04 mmol·L^(-1)),TG(>1.88 mmol·L^(-1)),LDL-C(>2.53 mmol·L^(-1)),FOXO3a(>4.65μg·L^(-1)),sICAM-1(>195.73μg·L^(-1)),and NLRP3(>1322.12 ng·L^(-1))were risk factors for coronary heart disease patients with HUA(P<0.05).ROC analysis showed that the area under the curve(AUC)of FOXO3a,sICAM-1 and NLRP3 in the combined diagnosis of coronary heart disease combined with HUA was 0.811,and the sensitivity and specificity were 95.16%and 67.02%,respectively,which was superior to the diagnosis of single index of each index and had high diagnostic efficacy(P<0.05).Conclusion FOXO3a,sICAM-1 and NLRP3 are involved in the occurrence of coronary heart disease complicated with HUA,and have high efficacy in clinical diagnosis of coronary heart disease complicated with HUA.
作者
闫国伟
刘雯
贾青霞
YAN Guowei;LIU Wen;JIA Qingxia(Department of Cardiovascular Medicine,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)
出处
《河南医学研究》
CAS
2024年第21期3900-3904,共5页
Henan Medical Research
