摘要
目的 探讨双能量CT(DECT)对痛风的诊断价值。方法 选取96例痛风患者作为观察组,另选取18例非痛风患者作为对照组;再将96例痛风患者根据有无痛风石分为痛风石组(16例)和无痛风石组(80例);根据病程将痛风患者分为早期(病程≤12个月, 17例)、中期(13~36个月, 12例)及晚期(病程>36个月, 67例);根据血尿酸水平高低将痛风患者分为正常尿酸组(尿酸≤420μmol/L, 29例)和高尿酸组(尿酸>420μmol/L, 67例)。所有患者均进行DECT检查。比较观察组和对照组患者、不同病程痛风患者、不同血尿酸水平痛风患者、有无痛风石患者的尿酸盐结晶沉积检出率。结果 观察组尿酸盐结晶沉积检出率为75.00%,高于对照组的5.56%,差异有统计学意义(P<0.05)。早期、中期及晚期痛风患者尿酸盐结晶沉积检出率分别为52.94%(9/17)、58.33%(7/12)、83.58%(56/67),比较差异有统计学意义(P<0.05),晚期>中期>早期。高尿酸组尿酸盐结晶沉积检出率76.12%高于正常尿酸组的72.41%,但差异无统计学意义(P>0.05)。痛风石组尿酸盐结晶沉积检出率100.00%高于无痛风石组的70.00%,差异有统计学意义(P<0.05)。结论 DECT对痛风的诊断价值显著,其可作为痛风早期及合并痛风石患者的诊断及评估病情的方法之一,对指导痛风治疗及疗效评估有重要的价值。
Objective To explore the diagnostic value of dual-energy CT(DECT)for gout.Methods 96 patients with gout were selected as the observation group,and another 18 non-gout patients were selected as the control group.96 gout patients were divided into the tophus group(16 cases)and the non-tophus group(80 cases)according to the presence or absence of tophus;the 96 gout patients were divided into the early stage(≤12 months,17 cases),the middle stage(13-36 months,12 cases)and the late stage(>36 months,67 cases)according to the duration of disease;and the gout patients were divided into the normal uric acid group(uric acid≤420μmol/L,29 cases)and the high uric acid group(uric acid>420μmol/L,67 cases)according to the level of blood uric acid.All patients underwent DECT examination.The detection rates of urate crystal deposition were compared between the observation group and the control group,patients with different duration of disease,patients with different levels of uric acid,and patients with or without tophus.Results The detection rates of urate crystal deposition was 75.00%in the osbservation group,which was higher than 5.56%in the control group,and the difference was statistically significant(P<0.05).The detection rates of urate crystal deposition in patients with early,middle and late stages were 52.94%(9/17),58.33%(7/12)and 83.58%(56/67),respectively,and the difference was statistically significant(P<0.05),with late stage>middle stage>early stage.The detection rate of urate crystal deposition in the high uric acid group was 76.12%,which was higher than 72.41%in the normal uric acid group,but the difference was not statistically significant(P>0.05).The detection rate of urate crystal deposition in the tophus group was 100.00%higher than 70.00%in the non-tophus group,but the difference was statistically significant(P<0.05).Conclusion DECT has significant diagnostic value for gout.It can be used as one of the methods to diagnose and evaluate the condition of early gout and patients with tophus,and it has important value to guide the treatment and efficacy evaluation of gout.
作者
史恒星
谢向良
柯丽萍
余敏
滕岩
董丹丹
姜鸿
SHI Heng-xing;XIE Xiang-liang;KE Li-ping(Department of Rheumatology,Maanshan People's Hospital,Maanshan 243000,China)
出处
《中国实用医药》
2024年第21期88-91,共4页
China Practical Medicine
基金
皖南医学院校级科学研究项目(项目编号:JXYY202006)。
