摘要
目的探究磺达肝癸钠联合利伐沙班预防骨科大手术患者术后下肢深静脉血栓形成(DVT)的临床效果。方法选取2021年12月—2022年12月菏泽市中医医院收治的116例骨科大手术患者为研究对象,按随机数字表法将其分为对照组与试验组,各58例,对照组采用利伐沙班治疗,试验组采用磺达肝癸钠联合利伐沙班治疗,比较两组的术后下肢DVT发生率、凝血指标、炎症指标、血细胞指标及不良反应发生情况。结果观察组术后下肢DVT发生率低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组纤维蛋白原(FIB)、D-二聚体(D-D)水平均低于对照组,组间差异有统计学意义(P<0.05)。两组治疗前后凝血酶时间、C反应蛋白水平、白细胞计数、血小板计数及血红蛋白水平比较,组间差异无统计学意义(P>0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论磺达肝癸钠联合利伐沙班可降低骨科大手术患者术后下肢DVT发生率,调节FIB、D-D水平,且对机体炎症指标、血细胞指标无明显影响,具有较高的安全性。
Objective To explore the clinical effect of fondaparinux combined with rivaroxaban in preventing deep vein thrombosis(DVT)of lower limbs after major orthopaedic surgery.Methods A total of 116 patients with major orthopaedic surgery treated in Heze Hospital of Traditional Chinese Medicine from December 2021 to December 2022 were selected as the research objects.They were divided into a control group and an experimental group according to random number table method,with 58 cases in each group.The control group was treated with rivaroxaban,and the experimental group was treated with fondaparinux combined with rivaroxaban.The incidence of DVT,coagulation index,inflammation index,blood cell index and adverse reactions were compared between the two groups.Results The incidence of DVT in observation group was lower than that in control group,the difference was statistically significant(P<0.05).After treatment,the levels of fibrinogen(FIB)and D-dimer(D-D)in observation group were lower than those in control group,and the differences between groups were statistically significant(P<0.05).There were no significant differences in thrombin time,C-reactive protein level,white blood cell count,platelet count and hemoglobin level between the two groups before and after treatment(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of sulfodaparine and rivaroxaban can reduce the incidence of DVT in lower limbs after major orthopedic surgery, regulate FIB and D-D levels, and have no significant effects on inflammation and blood cell indexes, so it has a high safety.
作者
张秀杰
ZHANG Xiujie(Department of Orthopedics and Traumatology,Heze Hospital of Traditional Chinese Medicine,Heze 274000,China)
出处
《反射疗法与康复医学》
2024年第18期128-131,共4页
Reflexology And Rehabilitation Medicine
基金
中国红十字基金会医学赋能公益专项基金
2021年临床菁英临床科研项目。
关键词
骨科大手术
磺达肝癸钠
利伐沙班
下肢深静脉血栓形成
Major orthopaedic surgery
Fondaparinux
Rivaroxaban
Deep vein thrombosis of lower limbs
