摘要
银屑病和动脉粥样硬化病情均较复杂且迁延难愈,遗传易感性、炎症反应和脂肪因子作用可能是二者共病的主要机制。中医学认为,热、毒、痰和瘀是二者共病的基本病理因素,相互交织导致病程较长。中医从整体观出发,对银屑病和动脉粥样硬化共病具有一定疗效,受到广泛关注。本文从遗传、炎症反应、脂肪因子作用方面概述银屑病与动脉粥样硬化共病的致病机制,梳理中药单体及复方治疗银屑病和动脉粥样硬化共病机制研究现况,为相关机制及临床研究提供参考。
Psoriasis and atherosclerosis are both complex and refractory.Genetic susceptibility,inflammatory response and the role of adipokines may be the main mechanisms of their comorbidity.TCM believes that heat,toxicity,phlegm,and blood stasis are the basic pathological factors of the comorbidity,which intertwine and lead to a longer course of disease.TCM,starting from the holistic concept,has a certain efficacy in the treatment of psoriasis and atherosclerosis,and has received widespread attention.This article reviewed the pathogenesis of psoriasis and atherosclerosis comorbidity from the aspects of heredity,inflammatory response,and the role of adipokines,and combed the current situation of the research on the mechanism of the treatment of psoriasis and atherosclerosis comorbidity with TCM monomer and compounds,providing references for related mechanisms and clinical research.
作者
刘闯
林立
安月鹏
任向前
杨素清
LIU Chuang;LIN Li;AN Yuepeng;REN Xiangqian;YANG Suqing(Heilongjiang University of Chinese Medicine,Harbin 150040,China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《中国中医药信息杂志》
CAS
CSCD
2024年第12期185-190,共6页
Chinese Journal of Information on Traditional Chinese Medicine
基金
国家自然科学基金(81973846)。
关键词
银屑病
动脉粥样硬化
中药
共病
炎症反应
脂肪因子
综述
psoriasis
atherosclerosis
Chinese materia medica
comorbidity
inflammatory response
adipokin
review
