摘要
围绝经期综合征是中医妇科常见的一种疾病,症状多以月经紊乱、潮热盗汗、失眠、情绪波动等为主。本病既可作为一种独立的疾病出现,也可合并多种临床疾病,严重影响患者的身心健康。笔者通过回顾近年来相关研究文献,发现中医药可以提高围绝经期综合征的临床有效率,且对围绝经期干眼、围绝经期骨质疏松症、围绝经期抑郁症、围绝经期高血压等均有较好的治疗效果。作用机制与其能够通过调节PI3K/Akt、CRTCI/CREB/BDNF、ERK1/2/CREB/BDNF/、ERα/PI3K/Akt/GABA、PI3K/Akt/mTOR等多种信号通路的表达,进而改善机体激素水平、情绪障碍、睡眠质量或调节卵巢功能、脂质代谢等相关。
Perimenopausal syndrome is a common gynecological disease in traditional Chinese medicine,characterized by symptoms such as menstrual disorders,hot flashes,night sweats,insomnia,and mood swings.This condition can occur independently or in conjunction with multiple clinical diseases,severely affecting patients′physical and mental health.Through a review of recent related research literature,the authors found that traditional Chinese medicine can enhance the clinical efficacy of perimenopausal syndrome and effectively treat associated conditions such as perimenopausal dry eye,osteoporosis,depression,and hypertension.The mechanisms involve regulation of various signaling pathways including PI3K/Akt,CRTCI/CREB/BDNF,ERK1/2/CREB/BDNF,ERα/PI3K/Akt/GABA,and PI3K/Akt/mTOR,thereby improving hormone levels,emotional disorders,sleep quality,ovarian function,and lipid metabolism.
作者
郑晓骏
张蕾
吴晓真
徐乐勤
吴小云
ZHENG Xiaojun;ZHANG Lei;WU Xiaozhen;XU Leqin;WU Xiaoyun(Xiamen Hospital of Traditional Chinese Medicine,Xiamen 361000,China;Xiamen Hospital,Beijing University of Chinese Medicine,Xiamen 361000,China;The Third Clinical Medical College,Fujian University of Traditional Chinese Medicine,Xiamen 361000,China)
出处
《中医药信息》
2024年第11期84-88,共5页
Information on Traditional Chinese Medicine
基金
厦门市医疗卫生指导性项目(3502Z20214ZD1151)。
关键词
中医药
围绝经期综合征
药理
临床
Traditional Chinese medicine
Perimenopausal syndrome
Pharmacology
Clinical
