摘要
糖尿病(DM)是一种多病因的代谢疾病,目前DM患病率高达12.8%。DM患者多合并多种疾病,心力衰竭风险增加,而且心血管疾病是其死亡的主要原因。面对如此严峻的形势,各种治疗方案层出不穷,但收效甚微,糖化血红蛋白(HbA1c)未达标率超过半数,合并肥胖、高脂血症、心脏疾病患者呈上升趋势。过多地摄入碳水化合物,最终导致胰岛β细胞衰竭;一味满足胰岛素需求,会加重肥胖和低血糖发生。低血糖与猝死有着密不可分的联系。胰岛素强化治疗在减少血肌酐增倍、终末期肾病及肾脏疾病死亡风险方面未见获益,也不能有效降低死亡和心血管事件风险,传统的治疗方法并不能明显改善DM患者预后。目前DM的治疗方向应把握“截断源头,开放出口”,而理解DM,或许应该引入更多领域的思考。
Diabetes mellitus(DM)is a multi-pathogenic metabolic disease with a current prevalence of 12.8%.DM patients uaually accompany with multiple complications,in which cardiovascular disease is the main cause of death,the risk of heart failure has increased.Facing such a severe situation,various treatments have arised,but more than half patients′glycosylated hemoglobin(HbA1c)failed to meet the standard rate.Obesity,hyperlipidemia,heart disease showed an upward trend.Excessive intake of carbohydrates may lead to islet beta cell failure.Blindly meeting insulin needs will aggravate obesity hypoglycemia.Studies have shown that hypoglycemia is inextricably linked to sudden death.There is evidence that insulin intensive therapy has no significant benefits in reducing the risk of increased blood creatinine,end-stage kidney disease and kidney disease death.This therapy cannot effectively reduce the risk of death and cardiovascular events.It can be seen that the traditional treatment cannot meet our expectation.At present,the treatment direction of DM should focus on"cutting off the source and opening up the outlet",and understanding DM should introduce more fields of thinking and methods.
作者
林森
汤其强
方琨
姜良华
宋一全
LIN Sen;TANG Qiqiang;FANG Kun;JIANG Lianghua;SONG Yiquan(Department of Endocrinology,the Affiliated Hospital of Qingdao University,Qingdao 266000,China;不详)
出处
《中国临床保健杂志》
CAS
2024年第5期717-720,共4页
Chinese Journal of Clinical Healthcare
