摘要
目的:分析矮小症患儿左旋多巴联合精氨酸生长激素激发试验结果特征。方法:选取2020年12月—2023年2月苏州市吴江区儿童医院收治的100例矮小症患儿作为观察对象,均实施左旋多巴联合精氨酸生长激素激发试验,根据试验结果将100例患儿分为生长激素缺乏组、生长激素正常组,统计两组患儿具体情况以及生长激素峰值出现时间,对比两组体格指标、实验室指标。结果:试验检出68例生长激素缺乏患儿,其中62例为特发性生长激素缺乏,6例为其他;32例为生长激素正常患儿,其中28例为特发性矮小,4例为其他。两组患儿生长激素峰值出现时间多数在左旋多巴联合精氨酸生长激素激发试验后30 min和120 min,两组生长激素峰值出现时间分布比较,差异无统计学意义(P>0.05)。相较于生长激素正常组,生长激素缺乏组患儿年龄更大,体质量指数更高,身高标准差更高,差异有统计学意义(P<0.05)。相较于生长激素正常组,生长激素缺乏组患儿胰岛素生长因子1、血清25-羟维生素D水平更低,差异有统计学意义(P<0.05)。结论:左旋多巴联合精氨酸生长激素激发试验可作为儿童生长激素缺乏的诊断性试验,矮小症患儿生长激素缺乏与多种因素有关,诊断矮小症需要综合考虑多种因素。
Objective:To analyze the characteristics of L-dopa combined with arginine growth hormone stimulation test in children with nanosomia.Methods:A total of one hundred children with nanosomia treated in Suzhou Wujiang Children's Hospital from December 2020 to February 2023 were selected as the subjects of observation.All of them were subjected to L-dopa combined with arginine growth hormone stimulation test.According to the test results,one hundred children were divided into growth hormone deficiency group and normal growth hormone group.The specific conditions of the two groups of children and the occurrence time of growth hormone peak were analyzed,and the physical indexes and laboratory indexes were compared between the two groups.Results:68 children with growth hormone deficiency were detected,of which 62 were idiopathic growth hormone deficiency and 6 were other;there were 32 normal children with growth hormone,28 idiopathic nanosomia and 4 others;the peak time of growth hormone in the two groups was mostly 30 min and 120 min after L-dopa combined with arginine growth hormone stimulation test.,there was no statistical significance in the distribution of peak time of growth hormone between the two groups(P>0.05);compared with normal growth hormone group,children in growth hormone deficiency group were older,higher body mass index and higher standard deviation of height,and the differences were statistically significant(P<0.05);compared with normal growth hormone group,the levels of insulin growth factor 1 and serum 25-hydroxyvitamin D in growth hormone deficiency group were lower,and the difference was statistically significant(P<0.05).Conclusion:L-dopa combined with arginine growth hormone stimulation test can be used as a diagnostic test for growth hormone deficiency in children.Growth hormone deficiency in children with nanosomia is related to many factors,and the diagnosis of nanosomia requires comprehensive consideration of many factors.
作者
陆云
Lu Yun(Department of Clinical Laboratory,Suzhou Wujiang Children's Hospital,Suzhou 215200,Jiangsu Province,China)
出处
《中国社区医师》
2024年第30期89-91,共3页
Chinese Community Doctors
