摘要
目的 探索帕罗西汀联合认知行为疗法在肺癌化疗患者中的应用。方法 回顾性选取我院2020年6月~2022年9月108例肺癌化疗患者为研究对象,抽签法分为西药组和认知组,各54例。西药组予帕罗西汀治疗,认知组在帕罗西汀基础上联合认知行为疗法治疗,对比两组心理应激、癌因性疲乏、神经递质水平。结果 认知组治疗12周后汉密尔顿焦虑量表、汉密尔顿抑郁量表、躯体感知疲乏、行为疲乏、认知疲乏、情感疲乏评分低于西药组;5-羟色胺、脑源性神经营养因子水平高于西药组(P<0.05)。结论 帕罗西汀联合认知行为疗法可调节肺癌化疗患者神经递质水平,改善心理应激,减轻癌因性疲乏。
Objective To explore the application value of paroxetine combined with cognitive behavioral therapy in patients with lung cancer chemotherapy.Methods A total of 108 patients with lung cancer receiving chemotherapy in our hospital from June 2020 to September 2022 were retrospectively selected as the study objects,and were divided into Western medicine group and cognitive group by drawing lots,with 54 cases in each group.The western medicine group was treated with paroxetine,and the cognitive group was added with cognitive behavioral therapy.Psychological stress,cancer-related fatigue and neurotransmitter levels were compared between the two groups.Results After 12weeks of treatment,the scores of Hamilton Anxiety Scale,Hamilton Depression Scale,physical perception fatigue,behavioral fatigue,cognitive fatigue and emotional fatigue in the cognitive group were lower than those in the western medicine group.The levels of 5-hydroxytryptamine and Brain-derived neurotrophic factor were higher than those in the western drug group(P<0.05).Conclusion Paroxetine combined with cognitive behavioral therapy can regulate the level of neurotransmitters,improve psychological stress and reduce cancer-induced fatigue in patients with lung cancer chemotherapy.
作者
张洁
皇甫娟
曹贝贝
陈苗
赵文博
张远
ZHANG Jie;HUANG Fujuan;CAO Beibei(Jiaozuo People's Hospital,Jiaozuo 454000,China)
出处
《国际精神病学杂志》
2024年第5期1543-1545,1550,共4页
Journal Of International Psychiatry
基金
河南省医学科技攻关计划项目(编号:LHGJ20200835)。
关键词
帕罗西汀
认知行为疗法
肺癌
心理应激
癌因性疲乏
Paroxetine
Cognitive hehavioral therapy
Lung cancer
Psychological stress
Cancerous fatigue
