摘要
目的:观察养目汤加味联合羟苯磺酸钙胶囊治疗非增殖期糖尿病视网膜病变(NPDR)肝肾亏虚、目络失养证的临床疗效及对血清趋化因子样受体1(CMKLR1)、卵泡抑素样蛋白1(FSTL1)、C1q/肿瘤坏死因子相关蛋白9(CTRP9)水平的影响。方法:采用随机数字表法将82例NPDR肝肾亏虚、目络失养证患者分为治疗组与对照组各41例。对照组给予羟苯磺酸钙胶囊治疗,治疗组给予养目汤加味联合羟苯磺酸钙胶囊治疗,2组均连续治疗12周。比较2组治疗前后视力、眼压、眼底指标、中医证候评分及血清CMKLR1、FSTL1、CTRP9水平,并评估2组临床疗效及不良反应发生情况。结果:治疗组总有效率92.68%,高于对照组73.17%(P<0.05)。2组治疗后循环时间、血管渗漏面积、微血管瘤个数、毛细血管无灌注区面积较治疗前减少(P<0.05),中医证候评分、眼压及血清CMKLR1、FSTL1水平降低(P<0.05),且治疗组循环时间、血管渗漏面积、微血管瘤个数、毛细血管无灌注区面积少于对照组(P<0.05),中医证候评分、眼压及血清CMKLR1、FSTL1水平均低于对照组(P<0.05)。2组治疗后视力及血清CTRP9水平均较治疗前升高(P<0.05),且治疗组视力及血清CTRP9水平高于对照组(P<0.05)。2组未见明显不良反应。结论:养目汤加味联合羟苯磺酸钙胶囊治疗NPDR肝肾亏虚、目络失养证疗效确切,能够抑制机体炎症,保护患者视网膜屏障,提高视力,安全性较好。
Objective:To observe the clinical effect of the combination use of modified Yangmu Decoction and Calcium Dobesilate Capsules on nonproliferative diabetic retinopathy(NPDR)with liver-spleen deficiency syndrome and ocular vessel malnutrition syndrome and its effects on the levels of serum chemokine-like receptor 1(CMKLR1),follistatin-like protein 1(FSTL1)and C1q/tumor necrosis factor-related protein 9(CTRP9).Methods:A total of 82 NPDR patients with liver-spleen deficiency syndrome and ocular vessel malnutrition syndrome were divided into the treatment group and the control group according to the random number table method,with 41 cases in each group.The control group was treated with Calcium Dobesilate Capsules,and the treatment group was treated with modified Yangmu Decoction combined with Calcium Dobesilate Capsules.Both groups were treated for 12 weeks.The visual acuity,intraocular pressure,fundus indexes,traditional Chinese medicine(TCM)syndrome scores and levels of serum CMKLR1,FSTL1 and CTRP9 were compared before and after treatment between the two groups;the clinical effects and incidence of adverse reactions in the two groups were evaluated.Results:The total effective rate was 92.68%in the treatment group,higher than that of 73.17%in the control group(P<0.05).After treatment,the cycle time,areas of vascular leakage,number of microaneurysms,areas of capillary non-perfusion,TCM syndrome scores,intraocular pressure and levels of serum CMKLR1 and FSTL1 in the two groups were lower than those before treatment(P<0.05),and the cycle time,areas of vascular leakage,number of microaneurysms,areas of capillary non-perfusion,TCM syndrome scores,intraocular pressure and levels of serum CMKLR1 and FSTL1 in the treatment group were lower than those in the control group(P<0.05).After treatment,the visual acuity and levels of serum CTRP9 in the two groups were higher than those before treatment(P<0.05),and the visual acuity and serum CTRP9 level in the treatment group were higher than those in the control group(P<0.05).No obvious adverse reactions were found in the two groups.Conclusion:The combination use of modified Yangmu Decoction and Calcium Dobesilate Capsules has a definite curative effect on NPDR with liver-spleen deficiency syndrome and ocular vessel malnutrition syndrome,which can inhibit the inflammation of the body,protect the retinal barrier of patients and enhance the visual acuity with great safety.
作者
毛景璟
郝建春
阮静雅
MAO Jingjing;HAO Jianchun;RUAN Jingya(Department of Ophthalmology,Jinhua Eye Hospital,Jinhua Zhejiang 321000,China;Department of Chinese Medicine,Jinhua Hospital of Traditional Chinese Medicine,Jinhua Zhejiang 321000,China)
出处
《新中医》
CAS
2024年第22期24-28,共5页
New Chinese Medicine
