摘要
N6-甲基腺嘌呤(N6-methyladenosine,m^(6)A)是真核生物中最常见的RNA修饰类型,通过甲基转移酶、去甲基化酶和m^(6)A结合蛋白的动态可逆性调控影响细胞内的RNA代谢,控制相关病理生理过程的基因表达。近年来,m^(6)A甲基化修饰参与神经病理性疼痛的研究成为热点,一些新的认识不断涌现,m^(6)A甲基化修饰成为治疗神经病理性疼痛的潜在生物靶点。本文就m^(6)A甲基化修饰在神经病理性疼痛中的作用和调控机制进行综述,以期为神经病理性疼痛的药物开发和治疗提供新的启示。
N6-methyladenosine(m^(6)A)is the most common type of RNA modification in eukaryotes,which affects intracellular RNA metabolism and controls gene expression of related pathophysiological processes through dynamic reversible regulation of methyltransferases,demethylases and m^(6)A-binding proteins.In recent years,the involvement of m^(6)A methylation in the study of neuropathic pain has become a hot topic,some new understandings have been emerging,and m^(6)A methylation has become a potential biological target for the treatment of neuropathic pain.Therefore,this article reviews the role and regulation of m^(6)A methylation in neuropathic pain,in order to provide new enlightenment for the drug development and treatment of neuropathic pain.
作者
张玉婷
张励才
ZHANG Yu-Ting;ZHANG Li-Cai(Jiangsu Provincial Key Laboratory of Anesthesiology,Xuzhou Medical University,Xuzhou 221004,China)
出处
《生理学报》
CAS
CSCD
北大核心
2024年第5期809-817,共9页
Acta Physiologica Sinica
基金
supported by the National Natural Science Foundation of China,2022 Original Exploration Program Recommended by Experts (No.82150007)。
