摘要
目的:探究扶正清解方治疗浊瘀痹结型痛风性关节炎患者疗效及对中医证候积分和血尿酸水平的影响。方法:按简单随机化分组法将2021年1月~2023年10月期间我院就诊的浊瘀痹结型痛风性关节炎患者分为观察组和对照组,各56例。对照组接受清浊颗粒治疗;观察组在对照组基础上接受扶正清解方治疗。对比两组患者在治疗1个月后的临床疗效,并评估治疗前和治疗1个月后的中医证候积分、疼痛情况[视觉模拟评分(VAS)]、血清指标水平和炎症水平,并比较两组患者治疗期间不良反应和治疗1个月后的复发情况。结果:治疗1个月后,观察组的总有效率显著高于对照组( P <0.05)。治疗1个月后,两组患者的中医证候积分、VAS评分、血尿酸(UA)、血沉(ESR)、炎症水平较治疗前显著降低,且观察组低于对照组( P <0.05);两组患者的24h尿酸排出量(24h UUA)较治疗前显著提高,且观察组高于对照组( P <0.05)。治疗期间,两组患者不良反应发生率差异不显著( P >0.05);治疗1个月后,观察组的复发率显著低于对照组( P <0.05)。结论:采用扶正清解方治疗浊瘀痹结型痛风性关节炎患者疗效显著,有效改善中医证候积分、血清指标水平和炎症水平,缓解疼痛,降低复发,具有较好的安全性。
Objective: To explore the efficacy of Fuzheng Qingjie decoction in the treatment of patients with gouty arthritis of turbidity stasis obstruction type and its influence on TCM syndromes scores and blood uric acid level. Methods: According to the simple randomization grouping method, the patients with turbidity stasis obstruction type of gouty arthritis in our hospital from January 2021to October 2023were divided into observation group(56cases) and control group(56cases). The control group received Qingzhuo granule treatment, while the observation group was treated with Fuzheng Qingjie decoction on the basis of the control group. The clinical efficacy of the two groups of patients after 1month of treatment was compared, and the TCM syndromes scores, pain status [Visual Analogue Scale(VAS)], serum indicators and inflammatory indicators were evaluated before treatment and after 1month of treatment. The adverse reactions during treatment and recurrence status after 1month of treatment were compared. Results: The total effective rate in observation group after 1month of treatment was significantly higher than that in control group( P <0.05). The TCM syndromes scores, VAS score, blood uric acid(UA), erythrocyte sedimentation rate(ESR) and inflammatory indicators in the two groups were significantly reduced after 1month of treatment than those before treatment, and the above indicators in observation group were lower( P <0.05). The 24h uric acid excretion(24h UUA) in both groups was significantly enhanced compared with that before treatment, and the observation group had higher 24h UUA than that in control group( P <0.05). During treatment, there were no significant differences in the incidence rates of adverse reactions between groups( P >0.05). The recurrence rate in observation group was significantly lower than that in control group after 1month of treatment( P <0.05). Conclusion: Fuzheng Qingjie decoction has a significant efficacy in the treatment of patients with gouty arthritis of turbidity stasis obstruction type. It can effectively improve the TCM syndromes scores, serum indicators and inflammatory indicators, relieve the pain, and reduce the recurrence, and it has good safety.
作者
吴怡
朱洁
牛文婷
苏晓婷
WU Yi;ZHU Jie;NIU Wenting(Wuyue Traditional Chinese Medicine Outpatient Department,Zhangjiagang Traditional Chinese Medicine Hospital,Zhangjiagang Jiangsu 215600,China;Geriatric Department of Jurong Traditional Chinese Medicine Hospital,Jurong Jiangsu 212400,China;Pukou Traditional Chinese Medicine Hospital in Nanjing,Nanjing Jiangsu 210000,China)
出处
《四川中医》
2024年第11期134-137,共4页
Journal of Sichuan of Traditional Chinese Medicine
关键词
扶正清解方
浊瘀痹结型
痛风性关节炎
中医证候积分
血尿酸水平
Fuzheng Qingjie decoction
Turbidity stasis obstruction type
Gouty arthritis
TCM syndromes scores
Blood uric acid level
