摘要
This work aims to develop fast T_(1)mapping methods for preclinical and clinical scanners based on subspace-constrained reconstructions.Two sequences are explored for rapid T_(1)characterizations:1)Interleaved spatiotemporal encoding incorporating variable repetition times.2)Inversion recovery gradient echo with random sampling of the phaseencoding(PE)dimension.For both sequences,the subspace reconstruction of the signal recovery was applied,to jointly reconstruct the down-sampled images while characterizing the T_(1)relaxation.In vivo scans on human brains and abdomens confirmed the efficiency of the proposed methods,including compatibility with breath-holding.In addition,Scans on animals with abdominal tumors and dynamic contrast-enhanced T_(1)mapping on kidneys support the applicability of the proposed methods also in preclinical settings.
基金
funded by the Israel Science Foundation(grants 3594/21 and 1874/22)
the Clore Institute for High Field Magnetic Resonance Imaging and Spectroscopy and by the Azrieli Institute for Brain Imaging(Weizmann Institute),by China Scholarship Council(CSC)grant 201806310085
the National Key Research and Development Program grant 2023YFE0113300
the Magnetic Resonance Technology Alliance of the Chinese Academy of Sciences Scientific Research Instrument and Equipment Development Project grant 2021GZL001
the Israel Cancer Research Foundation and by Israel's Planning and Budget Committee(Lingceng Ma,international student fellowship).
