摘要
目的:观察全反式维甲酸(ATRA)和ATRA加小剂量三尖杉酯碱(LDH)治疗急性早幼粒细胞白血病(APL)的疗效。方法:66例急性早幼粒细胞白血病患者分成A、B两组:A组29例单用ATRA,B组37例ATRA和LDH合用。结果:完全缓解率A组为82.7％,B组为94.4％。两组完全缓解时间分别为39.50d±7.43d和24.12d±3.60d(P<0.001)。高白细胞综合征发生率分别为34.4％和5.5％(P<0.05)。结论:ATRA和LDH联合治疗APL可提高完全缓解率,缩短完全缓解时间,减少高白细胞综合征发生率,降低早期死亡率,因此本方法治疗APL有推广应用价值。
Objective: To investigate the efficacy of all - trans retinoic acid(ATRA) and low - dosage harringtonine(LDH) on acute promyelocytic leukemia(APL). Methods: Sixty-six patients were randomized into A and B groups, 29 cases were treated with ATRA alone and 37 cases with ATRA and LDH. Results: Complete remission (CR) was 82.7% in group A and 94.4% in group B. The time achieving CR was 39.50d?
出处
《中国临床医学》
2002年第5期483-485,共3页
Chinese Journal of Clinical Medicine
