摘要
目的 :探讨Fas、FasL蛋白在喉鳞癌 (LSCC)组织中的表达及意义。方法 :采用SABC免疫组化法检测 4 2例LSCC及 2 0例手术切缘正常组织中Fas及FasL ,并与LSCC病理分级、临床分期及颈淋巴结转移相比较。结果 :Fas及FasL在LSCC中阳性率分别为 4 7.6 %和 6 4 .3% ,与在正常喉组织阳性率 90 .0 %和 2 0 .0 %相比 ,差异有显著性意义 (P <0 .0 5 )。Fas阳性率与肿瘤分级分期无显著相关性 (P >0 .0 5 ) ,与肿瘤转移有关 (P <0 .0 5 ) ;FasL阳性率与肿瘤分级、分期及转移密切相关 (P <0 .0 5 )。Fas与FasL的表达无显著相关性。结论 :Fas及FasL表达异常可能参与喉鳞癌的发生和发展 ;检测Fas与FasL可望作为判定喉鳞癌预后的潜在指标。
Objective:To investigate the expression of Fas and FasL protein in squamous cell carcinoma of larynx (LSCC) and to evaluate its clinical significance.Method:Using immunohistochemical method SABC, we studied the expression of Fas and FasL protein in 42 cases of paraffin embedded LSCC tissues and in 10 cases of normal laryngeal tissues. The positive rates of Fas and FasL were compared with the pathological grade, clinical stage and cervical lymph node metastasis of LSCC.Result:The positive rates of Fas and FasL protein staining were 47.6 % and 64.3 % in 42 cases with LSCC, while they were 90.0 % and 20.0 % in the normal laryngeal tissues(P< 0.05 ) respectively. Fas was not related to the tumor grade and tumor stage(P> 0.05 ). However, Fas was significantly related to the metastasis(P< 0.05 ).On the other hand, FasL was positively related to the tumor grade, clinical stage and the metastasis(P< 0.05 ).No significant correlation has been noted between Fas and FasL.Conclusion:The results suggest that the aberrant expression of Fas and FasL is closely related to the genesis and progression of LSCC. Fas and FasL might be a predictor for the prognosis of LSCC.
出处
《临床耳鼻咽喉科杂志》
CSCD
北大核心
2002年第12期661-662,共2页
Journal of Clinical Otorhinolaryngology
