摘要
基因转移是基因治疗的关键技术 ,一直以来也是制约基因治疗成功开展的瓶颈问题 .随着纳米技术的发展 ,纳米基因转运体的研制获得了积极发展 ,其系统内和细胞内基因转移机理得到了深入阐明 .设计与研制在体内循环时间长、具有靶特异性的纳米转运体为突破基因转移瓶颈 ,实现安全。
Although genomic research has opened up more new avenues for therapeutic interventions based on genetic therapy, it will not be possible to realize the full potential of these therapies until the issue of gene delivery has been resolved. With the development of nanotechnology, the systemic and cellular mechanisms of nanoparticulate carriers for gene delivery have been gradually elucidated. Research and applications of long circulating and target specific nanoparticulate carriers maybe help to allevate the gene delivery bottleneck, and realize the efficient, targeted and safe gene delivery.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2002年第6期868-871,共4页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金资助项目 (3 0 1710 5 6)
教育部科学技术研究重点项目 (0 113 0 )
教育部重大项目基金 (2 0 0 0 15 6)
湖南省自然科学基金项目 (0 1JJY2 0 2 0 )~~
