摘要
通过对单药敏感试验 (即常规药敏试验 )和多药联合敏感试验结果的比较分析 ,证明这两种敏感试验的符合率在 95 %以上。结果显示 ,由抗性药物组成的化疗方案在体外对 4 0 %的菌株存在不同程度的抑菌效果 ,在 2种药物高度耐药、1种药物敏感时 ,病原菌在3种药物联合敏感试验中是敏感的。研究表明 ,根据多药联合敏感试验时受试株初生长时间、菌落数和菌落大小 ,可以比较准确的预测由抗性药物组成的化疗方案的敏感程度 ;在结核菌药敏试验中应采用匡氏琼脂培养基 。
The results of drug activity of singe drug and multidrug combination susceptibility tests showed the coincidence rate between the two kinds of tests was above 95% . The results also indicated that the chemotherapy program consisted of resistant drugs exhibited an inhibitory effects to different extents on the growth of 40% strains in vitro. Using two resistant drugs and one susceptible drug in the susceptibility test of three drug combination assay the pathogenic strain was still susceptible. It is proved that the extents of susceptibility of pathogenic strains to chemotherapy programs could be accurately calculated by the time of initial growth , the colony count and the colony size in multidrug combination susceptibility test. The results suggested Kuang′s agar medium should be adapted in the drug susceptibility test and the multidrug combination susceptibility test should be carried out for multidrug resistant strains of Mycobacterium tuberculosis.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2002年第11期1009-1011,共3页
Medical Journal of Chinese People's Liberation Army
