摘要
目的探讨经皮导管动脉化疗栓塞术(TACE)联合CT导向下125碘粒子植入与TACE联合射频消融治疗肝癌对术后复发和病人生存的影响,进一步明确两组治疗方法的疗效。方法选择60例原发肝癌患者,去除肝门部大血管旁及胆管、胆囊旁射频消融禁忌症,不适消融治疗病例,随机分成2组,30例TACE联合射频消融治疗为对照组,治疗组30例TACE+125碘粒子植入治疗,术后行肿瘤体积、血AFP值、血常规、肝功能指标、肝区疼痛、肿瘤复发、随访生存期对比。结果与射频消融治疗组相比,粒子植入治疗组术后累积复发率明显降低,差异有统计学意义(χ?=5.325 P=0.022);术后疼痛明显减少(χ?=7.68 P=0.012);术后累积生存率及术中出血无统计学差异(χ2=1.765 P=0.184);两组均未见胆漏、腹腔感染、肝肾功能衰竭。结论 TACE联合粒子植入治疗原发性肝癌较TACE联合射频消融治疗治疗原发性肝癌适应症更为宽广,疗效更为肯定。
Objective to investigate the effects of TACE combined with Iodine particles implantation and TACE combined with radiofrequency ablation on recurrence and patient's survival,further to identify the treatment effects. Method 60 primary liver cancer patients were selected and divided into two groups. 30 patients accepted TACE combined with Iodine particles and the other 30 accepted TACE combined with radiofrequency ablation. After surgery,the tumor volume,AFP in serum,blood routine examination,indexes of liver function,pain in liver,recurrence and survival period were compared. Results Compared to TACE combined with radiofrequency ablation group,TACE combined with Iodine particles implantation group showed smaller cumulative recurrence rate( χ2=5. 325,P = 0. 022) and less pain with significant differences( χ2= 7. 68 P = 0. 012). there were no significant differences in cumulative survival rate and bleeding in surgery. No bile leakage,Abdominal infection and liver and kidney failure in both of the two groups.Conclusion Compared to TACE combined with radiofrequency ablation group,TACE combined with Iodine particles implantation has more comprehensive applications and definite treatment effects.
出处
《肝胆外科杂志》
2015年第5期373-376,共4页
Journal of Hepatobiliary Surgery
关键词
TACE
125碘放射性粒子
射频消融
Transcatheter Arterial Chemoembolization
Radioactive iodine particles125
radiofrequency ablation
