摘要
本文就14年来本研究组的胆结石溶石研究进行概括总结。70年代本组首先开创一种由EDTA-2Na及胆汁酸盐组成的新药,经导管灌注溶解胆色素混合性胆石取得成功。尔后,在80年代以此加入桔皮油(其主要成分为右旋柠烯)制备乳剂(复方桔油乳剂-COPE)进一步提高了临床疗效。这是我们的第二代灌注溶石剂,并已于1989年通过了卫生部的新药审批。最近,另一种由MTBE与COPE组成的新复方乳剂(复方MTBE乳剂)—用于灌注疗法的第3代胆结石溶石剂的实验研究再次取得成功,并已开始进行临床观察。与此同时,一种由中药组成用于口服溶解胆石的新药—“金石散”也研究成功。在一系列实验研究基础上对36例胆石患者进行了初步的临床研究,经治疗2.8±1.55月,其中4例胆石消失,14例胆石明显减少或缩小,总有效率约50％。
The study of gallstone dissolution in our researsh group during last 14 years was summarized briefly in this article. In 70 decade, a new prescription composed of EDTA-2Na and bile salt (comlex bile salt infusion solution) for pigment mixed gallstone dissolution through cathter infusion had been performed successfully and firstly by our group. Thereafter, at 80 decade the clinical effecacy was further improved as it added with orange peel oil (its main component was d-limonene) to prepare an emulsion (complex orange peel oil emulsion COPE). It was our second generational cholelitholytic drug for infusion and had been passed the new drug examin a tion and approved of Chinese national public health ministry at 1989. Recently, the experimental study of another new complex emulsion composed of MTBE and COPE (complex MTBE emulsion) ……the 3rd generational cholelitholytic prescription for infusion therapy was performed successfully once more, and became to bring up for clinical observation. Meanwhile, another new drug composed of Chinese traditional medicine named 'Jin Shi San' for gallstone dissolution per oral administration has been also studied successfully. Based on a serial experimental research, a preliminary clinical study was performed on 36 cases of biliary stone, among which gallstone disappeared in 4 cases, and with a tosal effecacy about 50% after a treatment for 2.8±1.55 months.
关键词
复方桔油乳剂
胆结石
溶石疗法
gallstone dissolusion
EDTA- '2Na-bile salt infusion solution
complex orange peel oil emulsion (COPE)
complex MTBE emulsion
'Jin Shi San'
