摘要
目的 :对国内外脑出血患者深静脉血栓形成的危险因素进行系统分析。方法 :计算机检索Pubmed、WebofScience、theCochraneLibrary、EMBASE、中国学术期刊数据库(CNKI)、万方数据库(Wanfang Data)、中国生物医学文献数据库(CBM),筛选脑出血患者深静脉血栓形成危险因素的相关文献。采用RevMan 5.3软件对纳入的文献进行分析,并用描述性分析的方法对脑出血患者深静脉血栓形成的危险因素进行补充分析。结果 :经检索共获得358篇文献,最终纳入10篇文献进入统计分析,涉及19 447例脑出血患者,其中1 104例合并深静脉血栓形成。Meta分析显示人口学资料中,肥胖[OR=9.45,95%CI(1.81,49.40),P=0.008]、年龄[OR=3.84,95%CI(2.57,5.75),P<0.001]是脑出血患者深静脉血栓形成的风险因素;房颤[OR=3.77,95%CI(2.83,5.02),P<0.001]、瘫痪[OR=6.73,95%CI(1.69,26.84),P=0.007]及平均住院日[OR=13.44,95%CI(11.97,14.90),P<0.001]是脑出血患者深静脉血栓形成的高危因素;基于美国国立卫生院脑卒中量表(NIHSS)评定的神经功能缺损程度,在西方国家是风险因素[OR=5.14,95%CI(3.32,6.97),P<0.001],但是在亚洲国家,此量表评定的神经功能缺损程度不是风险因素[OR=9.06,95%CI(0.58,142.66),P=0.12];D-二聚体[OR=607.42,95%CI(488.19,726.64),P<0.001]及[OR=8.24,95%CI(6.36,10.67),P<0.001],C反应蛋白(CRP)值[OR=8.43,95%CI(4.85,14.65),P<0.001]是高危因素。结论 :年龄增大、肥胖程度增大、瘫痪、并发房颤、较长住院日、较高D-二聚体及CRP值的脑出血患者发生深静脉血栓形成的可能性越大。
Objective:To have a systematic review on the risk factors of Deep Venous Thrombosis(DVT)in brain hemorrhage patients.Methods:We systematically reviewed all articles related to the DVT risk factors in brain hemorrhage patients including Pubmed,Web of Science,the Cochrane Library,EMBASE,CNKI,Wanfang Data and CBM.Metaanalysis was conducted for quantitative analysis using RevMan 5.3 and descriptive analysis was adpoted as a supplement.Results:A total of 358 papers were retrieved,and 10 papers were included in the Meta analysis involving 19,447 patients with cerebral hemorrhage,of which 1,104 were diagnosed with DVT.Meta analysis showed that obesity[OR=9.45,95%CI(1.81,49.40),P=0.008],age[OR=3.84,95%CI(2.57,5.75),P<0.001],atrial fibrillation[OR=3.77,95%CI(2.83,5.02),P<0.001],paralysis[OR=6.73,95%CI(1.69,26.84),P=0.007],D-dimer[OR=607.42,95%CI(488.19,726.64),P<0.001]/[OR=8.24,95%CI(6.36,10.67),P<0.001],CRP values[OR=8.43,95%CI(4.85,14.65),P<0.001]and the average hospitalization time[OR=13.44,95%CI(11.97,14.90),P<0.001]were risk factors for DVT in patients with brain hemorrhage.The degree of neurological deficit assessed by National Institutes of Health Stroke Scale(NIHSS)was more applicable for western countries[OR=5.14,95%CI(3.32,6.97),P<0.001],but not for Asian countries(OR=9.06,95%CI(0.58,142.66,P=0.12)Conclusion:Age,obesity,paralysis,atrial fibrillation,longer hospital stay,D-dimer and CRP were risk factors of DVT in patients with intracerebral hemorrhage,which could increase the incidence of DVT among those patients.
作者
姚文
王小玲
巩树梅
邹敏
张洪燕
YAO Wen;WANG Xiaoling;GONG Shumei;ZOU Min;ZHANG Hongyan(Nursing Department,Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,200092,China)
出处
《中国护理管理》
CSCD
北大核心
2019年第9期1322-1329,共8页
Chinese Nursing Management
基金
上海交通大学医学院2018年课题(Jyh1820)
关键词
脑出血
深静脉血栓
危险因素
META分析
系统评价
brain hemorrhage
Deep Venous Thrombosis
risk factors
Meta analysis
systematic review
