摘要
目的研究养血清脑颗粒配合西医对情绪障碍性失眠症患者睡眠质量及情绪障碍的改善作用。方法选取郑州颐和医院治疗的情绪障碍失眠患者78例,按照治疗方案不同分组,各39例。对照组予以盐酸帕罗西汀治疗;观察组予以盐酸帕罗西汀+养血清脑颗粒治疗。统计对比两组临床治疗效果及不良反应发生情况,治疗前后采用匹茨堡睡眠质量指数量表(PSQI)评估两组患者睡眠质量情况,采用汉密尔顿焦虑量表(HAMA)评估两组患者情绪障碍情况。结果观察组治疗有效率为94.87%(37/39),明显高于对照组的76.92%(30/39),差异有统计学意义(P<0.05);治疗后两组PSQI评分均较治疗前降低,且观察组PSQI评分低于对照组,差异有统计学意义(P<0.05);治疗后两组HAMA评分均较治疗前降低,且观察组HAMA评分明显低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为15.38%(6/39),与对照组的10.26%(4/39)比较,差异无统计学意义(P>0.05)。结论养血清脑颗粒配合西医治疗情绪障碍性失眠症患者临床疗效显著,能明显提高其睡眠质量,改善其情绪障碍,且具有较高安全性,值得推广。
Objective To explore the improvement effect of Yangxue Qingnao granule combined with Western medicine on sleep quality and emotional disorder in patients with emotional disorder insomnia. Methods 78 cases of patients with emotional disorder insomnia in Zhengzhou Yihe hospital were divided into control group and observation group according to the treatment regimen,with 39 cases in each group. The control group was treated with paroxetine hydrochloride,and the observation group was treated with paroxetine hydrochloride combined with Yangxue Qingnao granule. The clinical therapeutic effect and adverse reactions in the two groups were statistically analyzed,the Pittsburgh Sleep Quality Index( PSQI) was used to evaluate the sleep quality of the two groups before and after treatment,and the Hamilton Anxiety Scale( HAMA) was used to evaluate the emotional disorder. Results The effective rate of the observation group was94. 87%( 37/39),which was significantly higher than 76. 92%( 30/39) of the control group( P < 0. 05). PSQI scores after treatment in the two groups were lower than those before treatment,and the PSQI scores of the observation group was lower than that of the control group( P < 0. 05). The HAMA scores in the two groups after treatment were lower than those before treatment,and the HAMA scores of the observation group was significantly lower than that of the control group( P < 0. 05). The incidence of adverse reactions in the observation group was 15. 38%( 6/39),and it did not show any statistical difference comparing with 10. 26%( 4/39) of the control group( P > 0. 05). Conclusion Yangxue Qingnao granule combined with Western medicine in the treatment of emotional disorder insomnia got significantly clinical effect,and it can significantly improve patient's sleep quality and emotional disorder. It is safe,and is worthy of promotion.
出处
《光明中医》
2017年第12期1783-1785,共3页
GUANGMING JOURNAL OF CHINESE MEDICINE
关键词
不寐
盐酸帕罗西汀
养血清脑颗粒
情绪障碍性失眠症
中西医结合疗法
Insomnia
Paroxetine hydrochloride
Yangxue Qingnao granule
Emotional disorder insomnia
Therapy of integrated medicine
