摘要
目的观察复方四黄膏(由黄连、大黄、黄芩、黄柏、冰片及凡士林制成)治疗急性痛风性关节炎的临床疗效。方法将90例急性痛风性关节炎患者,随机分为对照组、观察组各45例。对照组予口服秋水仙碱片,观察组在对照组的基础上予外敷复方四黄膏,疗程均为7 d。对比2组患者治疗后的临床疗效,治疗前后的中医证候积分、疼痛视觉模拟(VAS)评分和红细胞沉降率(ESR)、C-反应蛋白(CRP)、血尿酸(BUA)指标的变化情况,以及评估2组的安全性。结果治疗后,观察组总有效率达95. 56%,对照组总有效率达91. 11%,观察组临床疗效明显优于对照组(P <0. 05)。治疗后2组患者的中医证候积分以及VAS评分均较治疗前降低(P <0. 05);其中观察组降低幅度明显优于对照组(P <0. 05)。治疗后2组患者的ESR、CRP、BUA均较治疗前降低(P <0. 05);其中2组患者BUA指标降低幅度无明显差异(P> 0. 05),而观察组的ESR和CRP两项指标降低幅度明显优于对照组(P <0. 05)。治疗前后2组患者的血常规、尿常规以及肝肾功能指标比较均无异常变化(P> 0. 05),但治疗过程中2组患者出现的不良反应比较,差异有统计学意义(P <0. 05),说明观察组安全性高于对照组。结论复方四黄膏治疗急性痛风性关节炎疗效可观,且安全性高,不仅可消肿止痛、缓解症状,还可降低炎症指标。
Objective To observe the clinical efficacy of compound Sihuang ointment(made of coptis,rhubarb,scutellaria,phellodendron,borneol and vaseline)in treating acute gouty arthritis.Methods 90 patients with acute gouty arthritis were selected and randomly divided into control group and observation group,with 45 cases in each group.The control group was received colchicine tablets orally,while observation group was received compound Sihuang ointment externally based on the treatment of control group.The treatment course was 7 days.Comparison was made on post-treatment clinical efficacy,traditional Chinese medicinesyndrome before and after treatment,and the changes of visual analogy score(VAS),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)and blood uric acid(BUA).Safety of both groups was also evaluated.Result After treatment,total effective rate of observation group was 95.56%,while the one of control group was 91.11%,which showed that the clinical efficacy of observation group was better than control group(P<0.05).After treatment,TCM syndrome and VAS of both groups were lower than the ones before treatment(P<0.05).Thereinto,the ones of observation group were lower(P<0.05).After treatment,ESR,CRP and BUA of both groups were lower than the ones before treatment.Thereinto,BUA reduction of both groups had no much difference,but ESR and CRP reduction of observation group were lower than the ones of control group(P<0.05).There were no abnormal changes in blood routine,urine routine and liver and kidney function indexes between both groups before and after treatment(P>0.05).There were significant differences in the adverse reactions between both groups during the treatment(P<0.05).Safety of observation group is higher than control group.Conclusion Compound Sihuang ointment has good efficacy and high safety in treating acute gouty arthritis.It not only relieves swelling and pain,but also reduces inflammation index.
作者
刘远超
谭宏韬
LIU Yuanchao;TAN Hongtao(Department of Internal Medicine,Huizhou Hospital of Traditional Chinese Medicine,Guangdong Province,Huizhou 516000,China)
出处
《光明中医》
2019年第14期2183-2186,共4页
GUANGMING JOURNAL OF CHINESE MEDICINE
