摘要
目的 探讨梗阻性黄疸患者并发肾功能损害时血清一氧化氮 (NO )的变化及其意义。方法 检测梗阻性黄疸并发肾功能损害患者 2 5例 ,并选取 2 6例健康人作对照。分别测定血清NO、一氧化氮合成酶 (NOS)活性、血尿素氮 (BUN )、肌酐 (Cr)值。结果 梗阻性黄疸组BUN和Cr均高于健康对照组 (P <0 .0 1) ,NO和NOS则低于健康对照组 (P <0 .0 1)。相关分析显示NO与BUN ,Cr呈负相关(P均 <0 .0 1)。结论 梗阻性黄疸患者并发肾功能损害时血清NO和NOS下降 ,提示NO在梗阻性黄疸时对肾功能有一定的保护作用。
ObjectiveTo study the significance of the change of serum nitric oxide(NO) level in the obstructive jaundice(OJ) patients complicated with renal dysfunction. MethodsWe studied the level of NO,BUN.Cr inserum and the activity of NOS in 25 OJ patients with renal dysfunction and 26 healthy adults (control group). ResultsThe patients' serum NO level and the activity of NOS were significantly lower than those in control group( P <0.01),whereas the serum BUN and Cr levels were significantly higher than those in control group( P <0.01).The linear correlation analysis showed that the serum NO had a negative correlation between serum BUN and Cr level (P <0.01). Conclusions The OJ patients with renal dysfunction may lead the decrease of serum NO level. NO may have some protective effects to the renal function in OJ patients.
出处
《中国普通外科杂志》
CAS
CSCD
2002年第11期671-673,共3页
China Journal of General Surgery
