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三叶肽与胃肠道溃疡

Trifoil peptide and gastrointestinal ulcer
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摘要 目的　介绍三叶肽在胃肠道溃疡预防和治疗中的作用。方法　对三叶肽的结构、分布、生理作用和机制 ,以及与胃肠道溃疡的关系作综述。结果　三叶肽可与黏液糖蛋白相互作用形成黏液胶样层 ,增强胃肠道黏膜的保护能力 ;通过调节细胞迁移 ,进行黏膜损伤后的修复 ;并具有抗增殖、抗凋亡作用。三叶肽在胃肠道溃疡病中表达异常。在胃肠道溃疡周围存在溃疡相关细胞系 (UACL) ,UACL可产生新细胞迁移到溃疡表面 ,促进溃疡修复 ,并表达三叶肽等。在动物实验性胃溃疡前后应用三叶肽 ,可保护或减轻黏膜损伤和促进损伤黏膜的修复。结论　三叶肽为胃肠道溃疡的预防和治疗提供了一个新途径。 ObjectiveTo introduce the effect of trifoil peptides on the protection and treatment of gastrointestinal ulcer(GIU). MethodsWe reviewed literatures about trifoil peptide in its structure, distribution, physiologic effect and mechanism, and its relation with GIU. Results Trifoil peptides formed a layer of mucus glue by combining with glycoprotein ,and improved the defense ability of the gastrointestinal(GI) mucosa .Trifoil peptides repaired the GI mucosa by abjusting the movement of mucosal cells. Trifoil peptides also had the effect of antiproliferation and antiapopotosis. There was an ulcer-associated cell lineage (UACL) around GIU. In GIU, trifoil peptides unusually expressed new cells coming from UACL moved to the surface of ulcer, and repaired the ulcer. UACL can express three trifoil peptides.Used before and after the experiment, trifoil peptides have the protective and therapeutic effect on the experiment gastroenteric ulcer. ConclusionsTrifoil peptides may offer a new method to prevent and treat GIU.
作者 吴斌 时德
机构地区 泸州医学院附属医院普外科 重庆医科大学附属一医院普外科
出处 《中国普通外科杂志》 CAS CSCD 2002年第11期682-684,共3页 China Journal of General Surgery
关键词 三叶肽 胃肠道溃疡 药物疗法 综述 PEPTIC ULCER/drag ther TRIFOIL PEPTIDE/ther use REVIWE LITERATURE
分类号 R573.1 [医药卫生—消化系统]
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参考文献27

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中国普通外科杂志
2002年 第11期

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