摘要
目的比较齐拉西酮与奥氮平对女性精神分裂症患者阴、阳性症状与内分泌代谢的影响。方法选取我院2015年6月～2017年6月收治的138例女性精神分裂症患者为研究对象,按随机数表法分为齐拉西酮组与奥氮平组,每组69例。齐拉西酮组给予齐拉西酮治疗,奥氮平组给予奥氮平治疗,均持续治疗6周。比较两组精神分裂严重程度,检测患者内分泌代谢指标,统计治疗期间不良反应发生率。结果齐拉西酮组治疗6周后阳性与阴性症状评分(PANSS)与奥氮平组比较差异无统计学意义。齐拉西酮组治疗6周后空腹血糖(FBG)、胰岛素抵抗指数(HOMA-IR)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)显著低于奥氮平组(P<0.05)。结论齐拉西酮与奥氮平对女性精神分裂症患者均具有良好疗效,但齐拉西酮对患者内分泌代谢影响小。
Objective To compare the effects of ziprasidone and olanzapine on negative-positive symptom and endocrine metabolism in female patients with schizophrenia. Methods 138 cases of female patients with schizophrenia from June 2015 to June 2017 in our hospital were selected for the study and divided into ziprasidone group and olanzapine group according to the random number table method,with 69 cases in each group. Ziprasidone group was given ziprasidone,and olanzapine group was given olanzapine,and they were persistently treated for 6 weeks. The severity of schizophrenia was compared between the two groups. The endocrine metabolic indicators were measured,and the incidence rate of adverse reactions during treatment was recorded. Results There was no significant difference in positive and negative symptom scale(PANSS)score between ziprasidone group and olanzapine group after 6 weeks of treatment.The levels of fasting blood glucose(FBG),homeostasis model assessment-insulin resistance index(HOMA-IR),total cholesterol(TC),triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C)in ziprasidone group were significantly lower than those in olanzapine group after 6 weeks of treatment(P<0.05). Conclusions Both ziprasidone and olanzapine have good efficacy on female patients with schizophrenia,but ziprasidone has little effect on endocrine metabolism.
作者
魏玲
龚飞中
熊生杰
何玉华
WEI Ling;GONG Feizhong;XIONG Shengjie(Zigong mental health center,Zigong 643020,China)
出处
《国际精神病学杂志》
2019年第1期106-108,112,共4页
Journal Of International Psychiatry
关键词
精神分裂症
女性
齐拉西酮
奥氮平
临床疗效
糖脂代谢
Schizophrenia
Female
Ziprasidone
Olanzapine
Clinical efficacy
Glucose and lipid metabolism
