摘要
目的分析帕罗西汀对脑卒中后焦虑抑郁患者负性情绪及血清细胞因子水平的影响。方法 111例脑卒中后焦虑抑郁患者采用随机数字表法分组,对照组55例给予盐酸舍曲林治疗,观察组56例使用帕罗西汀治疗,对比治疗后临床疗效、神经功能、焦虑抑郁情绪、血清细胞因子水平变化及安全性。结果观察组治疗后总有效率及5-HT水平高于对照组,NIHSS、HAMD、HAMA评分及Hcy、IL-1水平低于对照组(P<0.05);不良反应发生率8.93%低于对照组12.73%(P>0.05)。结论帕罗西汀较之舍曲林能更有效改善卒中后抑郁患者炎性因子失衡状态,改变神经生物学特性,促进神经递质传递及神经功能恢复,消除焦虑抑郁负性情绪,安全性高,效果确切。
Objective To analyze the changes of negative emotion and serum cytokine levels in patients with anxiety and depression after stroke using paroxetine. Methods A total of 111 patients with post-stroke anxiety and depression in our hospital were enrolled and divided in two groups by random number table.55 patients in the control group were treated with sertraline hydrochloride,and 56 patients in the observation group were treated with paroxetine. After treatment,clinical efficacy,neurological function,anxiety and depression Changes in mood,serum cytokine levels,and safety. Results The total effective rate and 5-HT level in the observation group were higher than those in the control group. The NIHSS,HAMD,HAMA scores and Hcy and IL-1 levels were lower than those in the control group(P<0.05). The incidence of adverse reactions in the observation group was 8.93%,which was lower than that in the control group. Group(12.73%,P>0.05). Conclusion Paroxetine can effectively improve the imbalance of inflammatory factors in patients with post-stroke depression,change neurobiological properties,promote neurotransmitter transmission and recovery of neurological function,eliminate negative emotions of anxiety and depression,and have high safety and effectiveness.
作者
夏海清
潘燕
杨海霞
米婷婷
XIA Haiqing;PAN Yan;YANG Haixia(Nanyang Central Hospital,Nanyang 473000,China)
出处
《国际精神病学杂志》
2019年第1期134-136,共3页
Journal Of International Psychiatry
