摘要
为了研究急性心肌梗死患者血清CK-MB、FIB与冠状动脉狭窄程度的相关性。本研究选择116例行冠状动脉造影检查者分为急性心肌梗死组(n=81)、对照组(n=35;冠状动脉造影阴性者)。用Gensini积分评定冠状动脉狭窄程度,根据评分将患者分为4组:Ⅰ组(0～7分) 8例,Ⅱ组(8～25分) 15例,Ⅲ组(26～46分) 30例及Ⅳ组(>46分) 28例。测定各组血清CK-MB、FIB水平,并进行比较。研究结果表明:对照组和急性心肌梗死组年龄、体重、身高、舒张压、收缩压、脉压、心律、吸烟率、血清总胆固醇(total cholesterol, TC)、甘油三酯(triglyceride, TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol, LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol, HDL-C)、左心室射血分数(left ventricular ejection fraction, LVEF)、左心室舒张末期容积(left ventricular end-diastolic volume, LVEDV)及左心室收缩末期容积(left ventricular endsystolic volume, LVESV)比较,差异无统计学意义(p>0.05)。对照组和急性心肌梗死各组间Gensini评分具有显著性差异(p<0.01)。对照组和Ⅰ、Ⅱ、Ⅲ、Ⅳ组之间血清CK-MB、FIB水平具有差异性,且有统计学意义(F=8.164, p<0.017; F=6.351, p<0.028)。对照组血清CK-MB与FIB水平与Gensini积分无相关性(r=0.13, p=0.35; r=0.19, p=0.27)。急性心肌梗死患者血清CK-MB与FIB水平和Gensini积分均呈正相关(r=0.66, p<0.001; r=0.77, p<0.001)。我们初步认为急性心肌梗死患者血清CK-MB和FIB水平显著升高,且与冠状动脉狭窄程度具有相关性。
In order to invest igate the correlation between levels of serum CK-MB,FIB and coronary artery stenosis in patients with acute myocardial infarction,we selected the 116 cases undergone coronary angiography to be divided into acute myocardial infarction group(n=81)and control group(n=35;negative coronary angiography).The degree of coronary artery stenosis was assessed by Gensini’s scores system,and the patients were redivided into 4 groups based on the Gensini’s scores:groupⅠ(0~7 scores,n=8),groupⅡ(8~25 scores,n=15),groupⅢ(26~46 scores,n=30)and groupⅣ(>46 scores,n=28).The levels of serum CK-MB and FIB were detected and compared.The results showed there were no significant difference in age,weight,height,diastolic pressure,systolic pressure,pulse pressure,cardiac rhythm,smoking rate,total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume(LVEDV)and left ventricular end-systolic volume(LVESV)among the control group and the acute myocardial infarction groups,while there was a significant difference in Gensini scores among the control group and the acute myocardial infarction groups(p<0.01).There were significant differences in the serum levels of CK-MB and FIB among the control group and theⅠ,Ⅱ,ⅢandⅣgroups(F=8.164,p<0.017;F=6.351,p<0.028).There was no correlation between serum CK-MB,FIB levels and Gensini scores in the control group(r=0.13,p=0.35;r=0.19,p=0.27).Serum CK-MB and FIB levels in patients with acute myocardial infarction were positively correlated with Gensini scores(r=0.71,p=0.015;r=0.65,p=0.034).We preliminarily believed that the serum levels of CKMB and FIB in patients with acute myocardial infarction would be significantly increased and positively correlated with the degree of coronary artery stenosis.
作者
胡玉海
田佩孚
Hu Yuhai;Tian Peifu(clinical laboratory,Wuhan Hankou Hospital)
出处
《基因组学与应用生物学》
CAS
CSCD
北大核心
2019年第4期1864-1868,共5页
Genomics and Applied Biology
